US4283412A
Expired / Lapsed
US
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Antibacterial compounds
Assignee: Beecham Group PLC
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Filing: 1979-06-11
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Granted: 1981-08-11
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Expires: 1999-06-11
Abstract
Abstract Esters of an acid of formula: <IMAGE> which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
Inventors
- 👤 Kong Luk
- 👤 John P. Clayton
- 👤 Norman H. Rogers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61P; A61P31/00; A61P31/04; C; C07; C07D; C07D407/00; C07D407/02; C07D407/06
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
144 words
A pharmaceutical composition for treating bacterial infections in humans and animals which comprises an antibacterially effective amount of a compound of the formula (II): ##STR30## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2 to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substittued by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety, in combination with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
144 words
A pharmaceutical composition for treating bacterial infections in humans and animals which comprises an antibacterially effective amount of a compound of the formula (II): ##STR30## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2 to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substittued by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety, in combination with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
10 words
A composition according to claim 1 wherein R is methylphenyl.
Claim 4
Dependent Claim
10 words
A composition according to claim 1 wherein R is ##STR31##
Claim 5
Dependent Claim
22 words
A composition according to claim 1 wherein the double bond in the compound of the formula (II) is in the E configuration.
Claim 6
Dependent Claim
12 words
A composition according to claim 1 wherein the compound is 1R,S-methoxycarbonyl-1R,S-cyclohexylmethyl monate.
Claim 7
Independent Claim
146 words
A method of treating bacterial infections in humans and animals which comprises administering to a human or animal in need of said treatment an antibacterially effective amount of a compound of the formula (II). ##STR32## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety.
Claim 8
Independent Claim
146 words
A method of treating bacterial infections in humans and animals which comprises administering to a human or animal in need of said treatment an antibacterially effective amount of a compound of the formula (II). ##STR32## wherein R is alkyl of 1 to 20 carbon atoms, alkenyl of 2to 8 carbon atoms or alkynyl of 2 to 8 carbon atoms substituted by cycloalkyl of 3 to 7 carbon atoms unsubstituted or substituted by alkyl of 1 to 6 carbon atoms or aryl unsubstituted or substituted by up to 5 substituents selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy, amino, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms, in the alkoxy moiety and alkoxycarbonyalkyl of 1 to 6 carbon atoms in the alkoxy moiety and 1 to 6 carbon atoms in the alkyl moiety.
Claim 9
Dependent Claim
10 words
A method according to claim 6 wherein R is methylphenyl.
Claim 10
Dependent Claim
10 words
A method according to claim 6 wherein R is ##STR33##
Claim 11
Dependent Claim
22 words
A method according to claim 6 wherein the double bond in the compound of the formula (II) is in the E configuration.
Claim 12
Dependent Claim
13 words
A method according to claim 6 wherein the compound 1R,S-methoxycarbonyl-1R,S-cyclohexylmethyl monate is administered.
References Cited (Backward Citations)
GB1395907A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-10 | 1985-02-09 | 1985-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-10 | 1989-02-09 | 1989-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-10 | 1993-02-09 | 1993-08-11 | $7700.00 | Window Closed / Lapsed |