US4289779A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial compounds
Assignee: Beecham Group PLC
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Filing: 1979-06-11
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Granted: 1981-09-15
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Expires: 1999-06-11
Abstract
Abstract Esters of an acid of formula: <IMAGE> which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
Inventors
- 👤 Kong Luk
- 👤 John P. Clayton
- 👤 Norman H. Rogers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61P; A61P31/00; A61P31/04; C; C07; C07D; C07D407/00; C07D407/02; C07D407/06
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
98 words
A pharmaceutical composition for the treatment of bacterial infections comprising an antibacterially effective amount of a compound of the formula: ##STR31## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo, in combination with a pharmaceutical carrier.
Claim 2
Dependent Claim
98 words
A pharmaceutical composition for the treatment of bacterial infections comprising an antibacterially effective amount of a compound of the formula: ##STR31## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo, in combination with a pharmaceutical carrier.
Claim 3
Dependent Claim
24 words
A pharmaceutical composition according to claim 30 wherein in said compound R is 2-oxo-4H-chromen-4-yl, 2-oxo-4-methyl-2H-chromen-7-yl, 2-methyl-4-oxo-4H-chromen-7-yl, 2-phenyl-4-oxo-4H-chromen-7-yl, 2-oxo-4-carbethoxy-2H-chromen-7-yl, 2-carbethoxy-4-oxo-4H-chromen-7-yl, quinol-8-yl, 2-pyridyl, 3-pyridyl, or 4-pyridyl.
Claim 4
Dependent Claim
20 words
A pharmaceutical composition according to claim 2 wherein the configuration of said compound about the depicted double bond is E.
Claim 5
Dependent Claim
17 words
A pharmaceutical composition according to claim 2 wherein R in said compound is 2-pyridyl, 3-pyridyl, or 4-pyridyl.
Claim 6
Dependent Claim
14 words
A pharmaceutical composition according to claim 2 wherein R in said compound is 3-pyridyl.
Claim 7
Dependent Claim
14 words
A pharmaceutical composition according to claim 2 wherein R in said compound is 2-oxo-4H-chromen-4-yl.
Claim 8
Independent Claim
105 words
The method of treating bacterial infections in humans and other animals which comprises administering to a human or other animal in need thereof an antibacterially effective amount of a compound of the formula: ##STR32## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo.
Claim 9
Independent Claim
105 words
The method of treating bacterial infections in humans and other animals which comprises administering to a human or other animal in need thereof an antibacterially effective amount of a compound of the formula: ##STR32## wherein R is a heterocyclic ring system comprising oxygen, nitrogen or sulfur as the hetero atom and containing six ring members in the hetero ring, said system being a monocyclic or a fused benzo bicyclic system and being unsubstituted or substituted with a member selected from the group consisting of alkyl of 1 to 6 carbon atoms, carbalkoxy of 1 to 6 carbon atoms in the alkoxy group, phenyl and oxo.
Claim 10
Dependent Claim
23 words
The method according to claim 7 wherein in said compound R is 2-oxo-4H-chromen-4-yl, 2-oxo-4-methyl-2H-chromen-7-yl, 2-methyl-4-oxo-4H-chromen-7-yl, 2-phenyl-4-oxo-4H-chromen-7-yl, 2-oxo-4-carbethoxy-2H-chromen-7-yl, 2-carbethoxy-4-oxo-4H-chromen-7-yl, quinol-8-yl, 2-pyridyl, 3-pyridyl, or 4-pyridyl.
Claim 11
Dependent Claim
19 words
The method according to claim 8 wherein the configuration of said compound about the depicted double bond is E.
Claim 12
Dependent Claim
16 words
The method according to claim 8 wherein R in said compound is 2-pyridyl, 3-pyridyl, or 4-pyridyl.
Claim 13
Dependent Claim
13 words
The method according to claim 8 wherein R in said compound is 3-pyridyl.
Claim 14
Dependent Claim
13 words
The method according to claim 8 wherein R in said compound is 2-oxo-4H-chromen-4-yl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-14 | 1985-03-16 | 1985-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-14 | 1989-03-16 | 1989-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-14 | 1993-03-16 | 1993-09-15 | $7700.00 | Window Closed / Lapsed |