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US4522811A
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Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
Assignee: Syntex USA LLC
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Filing: 1982-07-08
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Granted: 1985-06-11
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Expires: 2002-07-08
Abstract
Abstract Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.
Inventors
- 👤 Deborah A. Eppstein
- 👤 Elizabeth B. Fraser-Smith
- 👤 Thomas R. Matthews
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K38/00; A61K38/04; A61K38/14; A61K9/00; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
44 words
A method for enhancing the anti-infective activity of a muramyldipeptide (MDP) compound which method comprises serial intravenous injection to an animal in need thereof an anti-infective enhancing amount of unencapsulated MDP compound and liposomes within three hours of each other wherein said MDP compound.
Claim 2
Independent Claim
44 words
A method for enhancing the anti-infective activity of a muramyldipeptide (MDP) compound which method comprises serial intravenous injection to an animal in need thereof an anti-infective enhancing amount of unencapsulated MDP compound and liposomes within three hours of each other wherein said MDP compound.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein said liposomes and MDP compound are injected within two hours of each other.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said MDP compound is N-acetyldesmethylmuramyl-L-alanyl-D-isoglutamine.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the MDP compound is N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein the MDP compound is N-acetyldesmethylmuramyl-L-alpha-aminobutyryl-D-isoglutamine.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said MDP compound is N-acetylmuramyl-L-alpha-aminobutyryl-D-isoglutamine.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein said MDP compound is N-acetylmuramyl-L-valyl-D-isoglutamine.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein said MDP compound is N-acetylmuramyl-L-threonyl-D-isoglutamine.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein said MDP compound is N-acetylmuramyl-L-seryl-D-isoglutamine.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-10 | 1988-12-10 | 1989-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-10 | 1992-12-10 | 1993-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-10 | 1996-12-10 | 1997-06-11 | $7700.00 | Window Closed / Lapsed |