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US4508831A
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Anti-streptolysin O latex reagent and process for the preparation thereof
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1983-03-17
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Granted: 1985-04-02
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Expires: 2003-03-17
Abstract
Abstract A process for the preparation of an antistreptolysin O latex reagent and the reagent produced by such process. The reagent is prepared by reacting streptolysin O with a bifunctional low molecular weight compound and, in the preferred embodiment, with a gamma globulin or a Fab fragment thereof to form a product, which product is adsorbed to latex particles. The reagent is stable and may be used for the determination of antibodies to streptolysin O.
Inventors
- 👤 Tibor Toth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:30
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; G01N33/545; G01N33/547; G01N33/54353; G01N33/563; G01N33/569; G01N33/56911; G01N33/56944; G01N33/68; G01N33/6854; G01N33/6857; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S436/00; Y10S436/811; Y10S436/815
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
34 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound to form a product and adsorbing said product to latex particles.
Claim 2
Dependent Claim
34 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound to form a product and adsorbing said product to latex particles.
Claim 3
Dependent Claim
55 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound and with a compound selected from the group consisting of a gamma globulin and a Fab fragment of a gamma globulin to form a product and adsorbing said product to latex particles.
Claim 4
Dependent Claim
55 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting streptolysin O with a bifunctional low molecular weight compound and with a compound selected from the group consisting of a gamma globulin and a Fab fragment of a gamma globulin to form a product and adsorbing said product to latex particles.
Claim 5
Dependent Claim
48 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting a Fab fragment of a gamma globulin with a bifunctional low molecular weight compound, separating any excess or unreacted bifunctional low molecular weight compound, adding streptolysin O, and adsorbing the product to latex particles.
Claim 6
Dependent Claim
48 words
A process for the preparation of an antistreptolysin O latex reagent, which comprises reacting a Fab fragment of a gamma globulin with a bifunctional low molecular weight compound, separating any excess or unreacted bifunctional low molecular weight compound, adding streptolysin O, and adsorbing the product to latex particles.
Claim 7
Dependent Claim
18 words
The process as recited in claim 1, 2, or 3, wherein said latex particles are polystyrene homopolymer particles.
Claim 8
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 4.
Claim 9
Dependent Claim
18 words
The process as recited in claim 1, 2, or 3, wherein said latex particles are polystyrene copolymer particles.
Claim 10
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 6.
Claim 11
Dependent Claim
17 words
The process as recited in claim 1 or 2, wherein said gamma globulin is human gamma globulin.
Claim 12
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 8.
Claim 13
Dependent Claim
21 words
The process as recited in claim 1 or 2, wherein said Fab fragment is the Fab fragment of human gamma globulin.
Claim 14
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 10.
Claim 15
Dependent Claim
17 words
The process as recited in claim 1 or 2, wherein said gamma globulin is bovine gamma globulin.
Claim 16
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 12.
Claim 17
Dependent Claim
21 words
The process recited in claim 1 or 2, wherein said Fab fragment is the Fab fragment of a bovine gamma globulin.
Claim 18
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 14.
Claim 19
Dependent Claim
91 words
The process as recited in claim 1, 2, or 3, wherein said bifunctional compound is a compound selected from the group consisting of compounds of the following formulae: OHC--(CH.sub.2).sub.n --CHO wherein n =2-4 ##STR2## wherein z=--OCH 3 or --COOH ##STR3## wherein x=--CH 2 or --OCH 2 --CH 2 --CH 2 O-- ##STR4## wherein y=--OCH 3 or --CH 3 R.sup.1 --N═C═N--R.sup.2 wherein R 1 = ##STR5## --CH 3 , or --CH 2 --CH 2 --C 6 H 5 and R 2 =--(CH 2 ) 3 --N(CH 3 ) 2 .HCl or ##STR6##
Claim 20
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 16.
Claim 21
Dependent Claim
17 words
The process as recited in claim 1, 2, or 3, wherein said bifunctional compound is glutaric dialdehyde.
Claim 22
Dependent Claim
10 words
The antistreptolysin O latex reagent produced according to claim 18.
Claim 23
Dependent Claim
13 words
The antistreptolysin O latex reagent produced according to claim 1, 2, or 3.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-01 | 1988-10-01 | 1989-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-01 | 1992-10-01 | 1993-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-01 | 1996-10-01 | 1997-04-02 | $7700.00 | Window Closed / Lapsed |