N6-(1- and 2-benzocycloalkyl) adenosines

Claim 2

A compound of the formula ##STR6## wherein R 1 is of the formula ##STR7## in which n is 1; X is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, phenyl or phenyl substituted by halogen, hydroxy, lower alkoxy, amino or trifluoromethyl; Y is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy, or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl; Z and Z' are independently hydrogen, halogen, nitro, trifluoromethyl, amino, lower alkyl, hydroxy or lower alkoxy; R 3 is hydrogen or lower alkyl; R' is hydrogen, acetyl or benzoyl; R 2 is hydrogen or halogen; its diastereomers or mixtures thereof, or a pharmaceutically acceptable acid addition salt thereof.

Claim 3

A compound of the formula ##STR8## wherein R 1 is of the formula ##STR9## in which n is 1; X is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, phenyl or phenyl substituted by halogen, hydroxy, lower alkoxy, amino or trifluoromethyl; Y is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy, or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl; Z and Z' are independently hydrogen, halogen, nitro, trifluoromethyl, amino, lower alkyl, hydroxy or lower alkoxy; R 3 is hydrogen or lower alkyl; R' is hydrogen, acetyl or benzoyl, and R 2 is hydrogen or halogen; its diastereomers or mixtures thereof, or a pharmaceutically acceptable acid addition salt thereof.

Claim 4

A compound of the formula ##STR8## wherein R 1 is of the formula ##STR9## in which n is 1; X is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, phenyl or phenyl substituted by halogen, hydroxy, lower alkoxy, amino or trifluoromethyl; Y is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy, or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl; Z and Z' are independently hydrogen, halogen, nitro, trifluoromethyl, amino, lower alkyl, hydroxy or lower alkoxy; R 3 is hydrogen or lower alkyl; R' is hydrogen, acetyl or benzoyl, and R 2 is hydrogen or halogen; its diastereomers or mixtures thereof, or a pharmaceutically acceptable acid addition salt thereof.

Claim 5

A compound as claimed in claim 2, wherein X, Y, Z, and Z' are hydrogen.

Claim 6

A compound as claimed in claim 3, wherein R 2 is hydrogen or chlorine; R 3 is hydrogen, and n 1.

Claim 7

A compound as claimed in claim 4, wherein R' is hydrogen.

Claim 8

A compound as claimed in claim 5, and being N 6 -(1-indanyl)adenosine.

Claim 9

A compound as claimed in claim 6, and being N 6 -[1-(S)-indanyl]adenosine.

Claim 10

A compound as claimed in claim 6, and being N 6 -[1-(R)-indanyl]adenosine.

Claim 11

A compound of the formula ##STR10## wherein R 1 is of the formula ##STR11## in which n is 1 X is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, phenyl or phenyl substituted by halogen, hydroxy, lower alkoxy, amino or trifluoromethyl; Y is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy, or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl; Z and Z' are independently hydrogen, halogen, nitro, trifluoromethyl, amino, lower alkyl, hydroxy or lower alkoxy; R 3 is hydrogen or lower alkyl; R' is hydrogen, acetyl or benzoyl; R 2 is hydrogen or halogen; its diastereomers or mixtures thereof, or a pharmaceutically acceptable acid addition salt thereof.

Claim 12

A compound of the formula ##STR10## wherein R 1 is of the formula ##STR11## in which n is 1 X is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl, phenyl or phenyl substituted by halogen, hydroxy, lower alkoxy, amino or trifluoromethyl; Y is hydrogen, lower alkyl or lower alkyl terminally substituted by hydroxy, lower alkoxy, or carboxyl, OR where R is hydrogen, lower alkyl, lower alkanoyl or benzoyl; Z and Z' are independently hydrogen, halogen, nitro, trifluoromethyl, amino, lower alkyl, hydroxy or lower alkoxy; R 3 is hydrogen or lower alkyl; R' is hydrogen, acetyl or benzoyl; R 2 is hydrogen or halogen; its diastereomers or mixtures thereof, or a pharmaceutically acceptable acid addition salt thereof.

Claim 13

A compound as claimed in claim 9, wherein X, Y, Z, and Z' are hydrogen.

Claim 14

A compound as claimed in claim 10, wherein R 3 is hydrogen or methyl.

Claim 15

A compound as claimed in claim 10, wherein R 3 is hydrogen, and R 2 is hydrogen or chlorine.

Claim 16

A compound as claimed in claim 11, wherein R' is hydrogen.

Claim 17

A compound as claimed in claim 12, and being N 6 -(2-indanyl)adenosine.

Claim 18

A pharmaceutical composition comprising an antihypertensive effective amount of a compound according to claim 1 together with a pharmaceutically acceptable carrier.

Claim 19

A method for treating hypertension in mammals suffering therefrom comprising administering to such mammals a pharmaceutical composition according to claim 13.