2-amino-adenosine derivatives

Abstract

Abstract NOVEL 2-AMINO-ADENOSINE DRIVATIVES CHARACTERIZED BY CARDIAC AND CIRCULATORY ACTIVITY AND BY THEIR HIGH CORONARY SPECIFICITY HAVING THE FOLLOWING STRUCTURAL FORMULA: 2-NH2,6-(R1-N(-R2)-),9-(3,4,5-TRI(HO-)-2-TETRAHYDRO- PYRANYL)-9H-PURINE WHEREIN R1 IS HYDROGEN, A SUBSTITUTED OR UNSUBSTITUDED, SATURATED OR UNSATURATED, STRAIGHT OR BRANCHED CHAIN ALIPHATIC HYDROCARBON RADICAL, WHEREIN SAID SUBSTITUENT IS AT LEAST ONE OF AMINO, ALKYLAMINO, DIALKYLAMINO, ACYLAMINO, ALKOXY, ACYLOXY, HYDROXY, MERCAPTO, ALKYLMERCAPTO, CARBOXY, CARBOXY ALKYL OR CARBOXAMIDO AND R2 IS A SATURATED OR UNSATURATED CYCLOALKYL RADICAL WHICH CAN CARRY ENDOALKYLENE RADICALS OR ANNELLATED, SATURATED OR UNSATURATED CYCLIC ALIPHATIC HYDROCARBON RADICALS, WHEREIN SAID SUBA-X-3, WHEREIN A IS A SUBSTITUTED OR UNSUBSTITUTED, SATURATED OR UNSATURATED, STRAIGHT OR BRANCHED CHAIN, OR CYCLIC ALIPHATIC HYDROCARBON RADICAL, WHEREIN SAID SUBSTITUENT IS AT LEAST ONE OF HYDROXY, ACYLOXY, CARBOXY AND ARYL RADICALS, X IS A VALENCY BOND, AN OXYGEN OR SULFUR ATOM, ALKYLATED IMINO OR ACYLATED IMINO, AND B IS A SUBSTITUTED OR UNSUBSTITUTED ALKYL, ALKENYL, ARYL, FURYL, PYRIDYL, INDOLYL OR IMIDAZOLYL RADICAL, WHEREIN SAID SUBSTITUENT IS AT LEAST ONE OF HALOGEN, ALKYL, HALOALKYL, ALKOXY, ARYLOXY, ACYLOXY, HYDROXY, MERCAPTO, ALKYLMERCAPTO, NITRO, CARBOXY, CARBOXYLALKYL AND METHYLSULFONYLAMINO RADICALS.

Inventors

• 👤 Klaus Koch
• 👤 Erich Fauland
• 👤 Kurt Stach
• 👤 Max Thiel
• 👤 Wolfgang Schaumann
• 👤 Karl Dietmann

Bibliographic Details