US4497829A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing perfluorochemical emulsion artificial blood
Assignee: University of Pennsylvania
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Filing: 1983-08-19
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Granted: 1985-02-05
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Expires: 2003-08-19
Abstract
Abstract Particles of perfluoro compound with a lipid coating are emulsified by sonification in aqueous medium, wherein the proportion of perfluoro compound in the emulsion is preferably about 30-75% (w/v) and the proportion of lipid is preferably about 7-9% (w/v). In the resulting stable emulsion 95% of these particles having diameters less than 0.2 mu . The emulsion is useful as an artificial blood for transport and delivery of oxygen to body tissues.
Inventors
- 👤 Henry A. Sloviter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
64 words
A process for preparing a stable emulsion comprising: (a) dispersing purified lipid in a physiologically acceptable aqueous medium by sonication; (b) adding perfluoro compound to the dispersion formed in (a); (c) sonicating the mixture of lipid and perfluoro compound formed in (b) to form an emulsion of lipid-coated particles of perfluoro compound; and (d) centrifuging the emulsion formed in (c) to separate oversize particles.
Claim 2
Dependent Claim
64 words
A process for preparing a stable emulsion comprising: (a) dispersing purified lipid in a physiologically acceptable aqueous medium by sonication; (b) adding perfluoro compound to the dispersion formed in (a); (c) sonicating the mixture of lipid and perfluoro compound formed in (b) to form an emulsion of lipid-coated particles of perfluoro compound; and (d) centrifuging the emulsion formed in (c) to separate oversize particles.
Claim 3
Dependent Claim
22 words
A process according to claim 1 wherein the perfluoro compound is selected from the group consisting of perfluorodecalin, perfluorometheyldecalin, perfluorotripropylamine and perfluorotributylamine.
Claim 4
Dependent Claim
11 words
A process according to claim 2 wherein the lipid is lecithin.
Claim 5
Dependent Claim
12 words
A process according to claim 2 wherein the perfluoro compound is perfluorodecalin.
Claim 6
Dependent Claim
12 words
A process according to claim 2 wherein the perfluoro compound is perfluorotripropylamine.
Claim 7
Dependent Claim
8 words
A stable emulsion prepared according to claim 1.
Claim 8
Dependent Claim
8 words
A stable emulsion prepared according to claim 2.
Claim 9
Dependent Claim
8 words
A stable emulsion prepared according to claim 3.
Claim 10
Dependent Claim
8 words
A stable emulsion prepared according to claim 4.
Claim 11
Dependent Claim
8 words
A stable emulsion prepared according to claim 5.
Claim 12
Dependent Claim
66 words
A process for preparing a stable emulsion comprising: (a) dispersing purified lecithin in cold Tyrode solution (pH 7.4) by sonication; (b) repeating the sonication of said lecithin; (c) forming an emulsion by adding to said dispersed lecithin a perfluoro compound and sonicating the mixture, repeating said sonication with an interval between each sonication; (d) centrifuging said emulsion; and (e) discarding a bottom fraction of said emulsion.
Claim 13
Dependent Claim
66 words
A process for preparing a stable emulsion comprising: (a) dispersing purified lecithin in cold Tyrode solution (pH 7.4) by sonication; (b) repeating the sonication of said lecithin; (c) forming an emulsion by adding to said dispersed lecithin a perfluoro compound and sonicating the mixture, repeating said sonication with an interval between each sonication; (d) centrifuging said emulsion; and (e) discarding a bottom fraction of said emulsion.
Claim 14
Dependent Claim
8 words
A stable emulsion prepared according to claim 11.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-05 | 1988-08-06 | 1989-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-05 | 1992-08-06 | 1993-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-05 | 1996-08-06 | 1997-02-05 | $7700.00 | Window Closed / Lapsed |