US4496550A
Expired / Lapsed
US
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Oligosaccharides having selective anticoagulation activity
Assignee: Pfizer Health AB
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Filing: 1981-09-11
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Granted: 1985-01-29
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Expires: 2001-09-11
Abstract
Abstract The invention relates to an oligosaccharide which contains 4-8 monosaccharide units and which is characterized in that it contains at least one glucosamine unit which is 3-0-sulfated, and at least one additional glucosamine unit, whereby these units are linked via an intermediate monosaccharide unit, which is bound to the reducing end of the 3-0-sulfated glucosamine unit. The invention further relates to a pharmaceutical composition containing one or more such oligosaccharides, and to a process for the preparation of these oligosaccharides.
Inventors
- 👤 Ulf P. F. Lindahl
- 👤 Gudrun E. Backstrom
- 👤 John Y. L. Thunberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:47
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C07; C07H; C07H11/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
49 words
Oligosaccharide comprising 4-8 monosaccharide units, characterized in that it contains at least one glucosamine unit which is 3-O-sulfated, and at least one further glucosamine unit, whereby these units are connected by an iduronic unit linking monosaccharide unit, which is bound to the reducing end of the 3-O-sulfated glucosamine unit.
Claim 2
Dependent Claim
49 words
Oligosaccharide comprising 4-8 monosaccharide units, characterized in that it contains at least one glucosamine unit which is 3-O-sulfated, and at least one further glucosamine unit, whereby these units are connected by an iduronic unit linking monosaccharide unit, which is bound to the reducing end of the 3-O-sulfated glucosamine unit.
Claim 3
Dependent Claim
15 words
Oligosaccharide according to claim 1, characterized in that the 3-O-sulfated glucosamine unit also is 2-N-sulfated.
Claim 4
Dependent Claim
21 words
Oligosaccharide according to claim 1 or claim 2, characterized in that the said at least one further glucosamine unit is 2-N-sulfated.
Claim 5
Dependent Claim
18 words
Oligosaccharide according to claim 1, characterized in that the intermediate monosaccharide unit is a sulfated iduronic acid unit.
Claim 6
Dependent Claim
30 words
Oligosaccharide according to claim 1, characterized in that it contains a non-sulfated iduronic acid unit linked to position C 4 of the 3-O-sulfated glucosamine unit via two linking monosaccharide units.
Claim 7
Dependent Claim
21 words
Oligosaccharide according to claim 1, characterized in that its last unit is a 2,5-anhydro-D-mannose unit, which can be sulfated or non-sulfated.
Claim 8
Dependent Claim
26 words
Oligosaccharide according to claim 1, characterized in that it exhibits selective coagulation activity by affinity to antithrombine and increases the reactivity of antithrombine towards factor X.
Claim 9
Dependent Claim
18 words
Oligosaccharide according to claim 1, characterized in that it is a tetrasaccharide, pentasaccharide, hexasaccharide, heptasaccharide or an octasaccharide.
Claim 10
Dependent Claim
23 words
A pharmaceutical preparation, characterized in that it contains one or more oligosaccharides according to claim 1 in an amount sufficient for anticoagulation activity.
Claim 11
Dependent Claim
32 words
The oligosaccharide of claim 5 wherein one of the two linking monosaccharide units is an acetylated glucosamine unit, and the other of the two linking monosaccharide units is a glucuronic acid unit.
Claim 12
Dependent Claim
12 words
The oligosaccharide of claim 10 wherein said acetylated glucosamine unit is 6-O-sulfated.
Claim 13
Dependent Claim
21 words
Oligosaccharide according to claim 11 characterized in that its last unit is a 2,5-anhydro-D-mannose unit, which can be sulfated or non-sulfated.
Claim 14
Dependent Claim
11 words
The oligosaccharide of claim 12 wherein said 2,5-anhydro-D-mannose unit is sulfated.
Claim 15
Dependent Claim
18 words
Oligosaccharide according to claim 2 characterized in that the intermediate monosaccharide unit is a sulfated iduronic acid unit.
Claim 16
Dependent Claim
18 words
Oligosaccharide according to claim 14 characterized in that the said at least one further glucosamine unit is 2-N-sulfated.
Claim 17
Dependent Claim
30 words
Oligosaccharide according to claim 15 characterized in that it contains a non-sulfated iduronic acid unit linked to position C 4 of the 3-O-sulfated glucosamine unit via two linking monosaccharide units.
Claim 18
Dependent Claim
32 words
Oligosaccharide according to claim 16 wherein one of the two linking monosaccharide units is an acetylated glucosamine unit and the other of the two linking monosaccharide units is a glucuronic acid unit.
Claim 19
Dependent Claim
12 words
Oligosaccharide according to claim 17 wherein said acetylated glucosamine unit is 6-O-sulfated.
Claim 20
Dependent Claim
21 words
Oligosaccharide according to claim 18 characterized in that its last unit is a 2,5-anhydro-D-mannose unit, which can be sulfated or non-sulfated.
References Cited (Backward Citations)
GB2002406A
Cited
GB2035349A
Cited
EP0014184A2
Cited
US4303651A
Cited
EP0027089A1
Cited
US4401758A
Cited
US4401662A
Cited
US4281108A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-29 | 1988-07-30 | 1989-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-29 | 1992-07-30 | 1993-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-29 | 1996-07-30 | 1997-01-29 | $7700.00 | Window Closed / Lapsed |