Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use

Claim 1

A polypeptide of formula I ##STR7## wherein A is hydrogen, C 1-3 alkyl or an acyl group of the formula (a) R I CO-- wherein R I is C 1-20 alkyl, C 3-20 alkenyl, C 3-20 alkinyl, phenyl, naphthyl or C 7-10 (phenylalkyl); (b) R II SO 2 -- wherein R II is C 1-10 alkyl, phenyl or C 7-10 (phenylalkyl); (c) R III O--CO-- wherein R III is C 1-10 alkyl or C 7-10 (phenylalkyl); and (d) ##STR8## wherein R IV is hydrogen, C 1-10 alkyl, phenyl or C 7-10 (phenylalkyl) and R V is hydrogen or C 1-10 alkyl; A 1 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , esterified or amidated carboxy group of the formula R.sub.8 O--CO-- or R.sub.8 --NH--CO-- wherein R 8 is C 1-16 alkyl or an amide group of the formula R 9 --CO--NH-- wherein R 9 is C 1-15 alkyl; A 2 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, halogen, OH or NO 2 , A 3 is hydrogen, C 1-3 alkyl or C 1-3 alkoxy, Q is C 1-4 alkylene, >N--CH(Z)--CO-- is an (L)- or (D) phenylalanine residue optionally ring substituted by one or more members selected from the group consisting of halogen, NO 2 , NH 2 , OH, C 1-3 alkyl and C 1-3 alkoxy, B is --Phe-- optionally ring-substituted by one or more memebers selected from the group consisting of halogen, NO 2 , NH 2 , OH, C 1-3 alkyl and C 1-3 alkoxy, C is --Trp-- or (D)Trp-- optionally α-N-methylated and optionally benzene-ring-substituted by one or more members selected from the group consisting of halogen, NO 2 , NH 2 , OH, C 1-3 alkyl and C 1-3 alkoxy, D is --Lys-- optionally α-N-methylated and optionally ε-N-C 1-3 alkylated, E is --Thr-- F is a group of formula --COOR 1 , --CH 2 OR 2 , ##STR9## wherein R 1 is hydrogen or C 1-3 alkyl, R 2 is hydrogen or the residue of a physiologically acceptable, physiologically hydrolysable ester, R 3 is hydrogen or methyl, R 4 is --CH(R 5 )--X, R 5 is hydrogen, --(CH 2 ) 2 --OH, --(CH 2 ) 3 --OH, --CH 2 OH, --CH(OH)--CH 3 or isobutyl, X is a group of formula --COOR 1 , --CH 2 OR 2 or --CON(R 6 )R 7 wherein R 1 and R 2 have the meanings given above, R 6 is hydrogen or C 1-3 alkyl and R 7 is hydrogen, C 1-3 alkyl, phenyl or C 7-10 phenylalkyl, the group --CH(R 5 )--X having the (D)- or (L)-configuration, and Y 1 and Y 2 are each hydrogen or together represent a direct bond, whereby the residues in the 2- and 7-position each independently have the (L)- or (D)-configuration; said polypeptide being in free or pharmaceutically acceptable protected form; or a pharmaceutically acceptable salt or complex thereof.