US4493829A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bio-available succinylated protein-iron derivatives which do not cause gastric lesions, method of preparation and related pharmaceutical compounds
Assignee: Italfarmaco SpA
•
Filing: 1983-02-24
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Granted: 1985-01-15
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Expires: 2003-02-24
Abstract
Abstract The invention relates to succinylated proteins, with a degree of succinylation of between 20 to 100%, containing from 0.1 to 20% by weight of iron, obtained by treating succinylated proteins with iron salts in suitable pH ranges. The compounds in question, which are completely tolerated, are characterized by an optimum bioavailability of iron.
Inventors
- 👤 Giancarlo Sportoletti
- 👤 Piergiuseppe Pagella
- 👤 Pietro Cremonesi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:02
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/02; C07K14/00; C07K14/415; A; A61; A61P; A61P7/00; A61P7/06; C07K1/107; C07K1/1072; C07K1/1077; C07K1/14; C07K1/30; C07K14/435; C07K14/46; C07K14/47; C07K14/76; C07K14/77; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/832; Y10S530/843; Y10S530/846
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
17 words
A bio-available succinyl ferro-protein derivative obtained by reacting a succinylated animal or vegetable protein with ferro ions.
Claim 2
Dependent Claim
17 words
A bio-available succinyl ferro-protein derivative obtained by reacting a succinylated animal or vegetable protein with ferro ions.
Claim 3
Dependent Claim
19 words
A bio-available succinyl ferro-protein derivative according to claim 1 in which the ferro content is about 0.1-20% by weight.
Claim 4
Dependent Claim
24 words
A bio-available succinyl ferro-protein derivative according to claim 2 in which the degree of succinylation of the protein is from about 20 to 100%.
Claim 5
Dependent Claim
29 words
A bio-available succinyl ferro-protein derivative according to claim 3 in which the degree of succinylation is greater than 70% and the ferro content is greater than 4% by weight.
Claim 6
Dependent Claim
17 words
A bio-available succinyl ferro-protein derivative according to claim 4 in which the protein is a milk protein.
Claim 7
Dependent Claim
17 words
A bio-available succinyl ferro-protein derivative according to claim 4 in which the protein is an ovalbumin protein.
Claim 8
Dependent Claim
17 words
A bio-available succinyl ferro-protein derivative according to claim 4 in which the protein is a soya protein.
Claim 9
Independent Claim
51 words
A method for preparing a bio-available succinyl ferro-protein derivative which comprises reacting a succinylated animal or vegetable protein with a ferro salt in an aqueous medium at a pH of about 2-10 and isolating the resultant reaction product by precipitation at a pH of about 2-4 produced spontaneously or by acidification.
Claim 10
Independent Claim
51 words
A method for preparing a bio-available succinyl ferro-protein derivative which comprises reacting a succinylated animal or vegetable protein with a ferro salt in an aqueous medium at a pH of about 2-10 and isolating the resultant reaction product by precipitation at a pH of about 2-4 produced spontaneously or by acidification.
Claim 11
Dependent Claim
26 words
A method according to claim 8 in which the reaction between the succinylated protein and the ferro salt is conducted at a pH of about 7.
Claim 12
Independent Claim
50 words
A method for preparing a bio-available succinyl ferro-protein derivative which comprises reacting a succinylated animal or vegetable protein with a ferro salt in an aqueous medium at a pH of about 2-10 and isolating the resultant reaction product by separating the aqueous medium after adjusting the pH to about 7.
Claim 13
Independent Claim
50 words
A method for preparing a bio-available succinyl ferro-protein derivative which comprises reacting a succinylated animal or vegetable protein with a ferro salt in an aqueous medium at a pH of about 2-10 and isolating the resultant reaction product by separating the aqueous medium after adjusting the pH to about 7.
Claim 14
Dependent Claim
36 words
A pharmaceutical composition for treating sideropenic anaemia in animals and humans containing as the active ingredient an effective amount of a bio-available succinyl ferro animal or vegetable protein derivative in admixture with a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
36 words
A pharmaceutical composition for treating sideropenic anaemia in animals and humans containing as the active ingredient an effective amount of a bio-available succinyl ferro animal or vegetable protein derivative in admixture with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-15 | 1988-07-16 | 1989-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-15 | 1992-07-16 | 1993-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-15 | 1996-07-16 | 1997-01-15 | $7700.00 | Window Closed / Lapsed |