Patent US4489062A successfully refreshed from Google Patents.
US4489062A
Expired / Lapsed
US
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Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation
Assignee: Wellcome Foundation Ltd
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Filing: 1983-02-04
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Granted: 1984-12-18
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Expires: 2003-02-04
Abstract
Abstract Novel peptides of formula (I) X--Tyr--X.sup.2 --Gly--Phe(4NO.sub.2)--Pro--NH.sub.2 (I) and salts thereof, wherein X is hydrogen or an amidino group and X 2 is a radical selected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesic effect when administered to mammals. The compounds also exhibit antidiarrhoeal and antitussive activity and may thus be used in human or veterinary medicine for the relief or prevention of pain, for the treatment of diarrhoea or dysentery and for the suppression of cough.
Inventors
- 👤 Lawrence A. Lowe
- 👤 Terence W. Smith
- 👤 Samuel Wilkinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 02:53
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/70; C07K14/702; A; A61; A61P; A61P25/00; A61P25/04; A61K; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
33 words
A peptide of formula (I) X--Tyr--X.sup.2 --Gly--Phe(4NO.sub.2)--Pro--NH.sub.2 (I) or a pharmacologically acceptable salt thereof wherein X is hydrogen or an amidino group, and X 2 is a radical selected from D--S--methylmethionyl and D--arginyl.
Claim 2
Dependent Claim
33 words
A peptide of formula (I) X--Tyr--X.sup.2 --Gly--Phe(4NO.sub.2)--Pro--NH.sub.2 (I) or a pharmacologically acceptable salt thereof wherein X is hydrogen or an amidino group, and X 2 is a radical selected from D--S--methylmethionyl and D--arginyl.
Claim 3
Dependent Claim
16 words
A peptide according to claim 1 or a pharmacologically acceptable salt thereof wherein X is hydrogen.
Claim 4
Dependent Claim
15 words
A compound according to claim 1 which is H--Tyr--D--Arg--Gly--Phe(4NO.sub.2)--Pro.NH.sub.2 or a pharmacologically acceptable salt thereof.
Claim 5
Dependent Claim
26 words
A pharmaceutical formulation comprising a peptide according to any of claims 1 to 3, or a pharmacologically acceptable salt thereof, together with an acceptable carrier therefor.
Claim 6
Independent Claim
38 words
A method for the relief or prevention of pain in a mammal comprising administering to said mammal a non-toxic, analgesic amount of a peptide according to any of claims 1 to 3 or a pharmacologically acceptable salt thereof.
Claim 7
Independent Claim
38 words
A method for the treatment of diarrhoea or dysentery in a mammal comprising administering to said mammal a non-toxic, effective amount of a peptide according to any of claims 1 to 3 or a pharmacologically acceptable salt thereof.
Claim 8
Independent Claim
36 words
A method for the suppression of cough in a mammal comprising administering to said mammal a non-toxic, effective amount of a peptide according to any of claims 1 to 3 or a pharmacologically acceptable salt thereof.
Claim 9
Independent Claim
34 words
The method of providing peripheral analgesia in a mammal suffering from pain which comprises administering to a mammal an effective amount of the compound of pharmacologically acceptable salt of claims 1, 2, or 3.
Claim 10
Dependent Claim
12 words
pharmacologically acceptable salt of a peptide of claim 1, 2 or 3.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |