US4244944A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of diarrhoea and dysentery
Assignee: SmithKline Beecham Corp
•
Filing: 1978-07-24
•
Granted: 1981-01-13
•
Expires: 1998-07-24
Abstract
Abstract Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe(4NO2).ProNH2 and Tyr.D-Met(O).Gly.Phe(4NO2).ProNH2 as anti-diarrhoeals and anti-tussives.
Inventors
- 👤 Samuel Wilkinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:20
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K14/00; C07K14/435; C07K14/665; C07K14/675; C07K14/6755; A; A61; A61P; A61P1/00; A61P1/12; A61P25/00; A61P25/04; C07K14/70; C07K14/702; A61K; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
40 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr. D-Met. Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
40 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr. D-Met. Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Independent Claim
39 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr.D-Met(O). Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Independent Claim
39 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr.D-Met(O). Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Independent Claim
41 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of a compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ). Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Independent Claim
41 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of a compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ). Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Independent Claim
40 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of the compound H. Tyr. D-Met.Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Independent Claim
40 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of the compound H. Tyr. D-Met.Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Independent Claim
41 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr. D-Met. Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Independent Claim
41 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr. D-Met. Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Independent Claim
40 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Independent Claim
40 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
US4028319A
Cited
US4123523A
Cited
BE857138A
Cited
US4092304A
Cited
US4128541A
Cited
US4127531A
Cited
US4127533A
Cited
US4127523A
Cited
US4127532A
Cited
US4103005A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-13 | 1984-07-14 | 1985-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-13 | 1988-07-14 | 1989-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-13 | 1992-07-14 | 1993-01-13 | $7700.00 | Window Closed / Lapsed |