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Patent US4244944A successfully refreshed from Google Patents.
US4244944A
Expired / Lapsed
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Treatment of diarrhoea and dysentery
Assignee: SmithKline Beecham Corp
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Filing: 1978-07-24
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Granted: 1981-01-13
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Expires: 1998-07-24
Abstract
Abstract Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe(4NO2).ProNH2 and Tyr.D-Met(O).Gly.Phe(4NO2).ProNH2 as anti-diarrhoeals and anti-tussives.
Inventors
- 👤 Samuel Wilkinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:41
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K14/00; C07K14/435; C07K14/665; C07K14/675; C07K14/6755; A; A61; A61P; A61P1/00; A61P1/12; A61P25/00; A61P25/04; C07K14/70; C07K14/702; A61K; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
40 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr. D-Met. Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
40 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr. D-Met. Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Independent Claim
39 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr.D-Met(O). Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Independent Claim
39 words
A method for the treatment or prophylaxis of diarrhoea in a mammal comprising the administration to the mammal of a non-toxic, anti-diarrhoeal effective dose of Tyr.D-Met(O). Gly. Phe(4NO 2 ).ProNH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Independent Claim
41 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of a compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ). Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Independent Claim
41 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of a compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ). Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Independent Claim
40 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of the compound H. Tyr. D-Met.Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Independent Claim
40 words
A method for the induction of constipation in a mammal which comprises the administration to a mammal of an effective constipation induction amount of the compound H. Tyr. D-Met.Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Independent Claim
41 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr. D-Met. Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Independent Claim
41 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr. D-Met. Gly.Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Independent Claim
40 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Independent Claim
40 words
A method for the treatment of dysentery in a mammal which comprises the administration to a mammal of an effective dysentery treatment amount of the compound H. Tyr.D-Met(O).Gly. Phe(4NO 2 ).Pro.NH 2 or a pharmaceutically acceptable acid addition salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-13 | 1984-07-14 | 1985-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-13 | 1988-07-14 | 1989-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-13 | 1992-07-14 | 1993-01-13 | $7700.00 | Window Closed / Lapsed |