US4092304A
Expired / Lapsed
US
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4-Substituted enkephalin derivatives
Assignee: GD Searle LLC
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Filing: 1976-08-09
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Granted: 1978-05-30
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Expires: 1996-08-09
Abstract
Abstract Analogs of methionine 5 -enkephalin and leucine 5 -enkephalin wherein the L-phenylalanyl residue in position 4 has been substituted by various other amino acid residues are disclosed herein. These analogs exhibit agonist activity at opiate receptor sites and are thus useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.
Inventors
- 👤 David A. Jones, Jr.
- 👤 James M. Schlatter
- 👤 Richard A. Mikulec
- 👤 Judith A. Reuter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:46
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06156; A; A61; A61P; A61P1/00; A61P1/12; A61P25/00; A61P25/04; A61P43/00; C07K14/00; C07K14/435; C07K14/665; C07K14/70; C07K14/702; A61K; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
35 words
A compound of the formula H-Tyr-Gly-Gly-W-Y-OH wherein Y is Leu or Met; W is β-thienyl-Ala; and the stereochemical configuration of each of the optically active amino acid residues may independently be D, L, or DL.
Claim 2
Dependent Claim
35 words
A compound of the formula H-Tyr-Gly-Gly-W-Y-OH wherein Y is Leu or Met; W is β-thienyl-Ala; and the stereochemical configuration of each of the optically active amino acid residues may independently be D, L, or DL.
Claim 3
Dependent Claim
9 words
The compound according to claim 1 which is L-tyrosylglycylglycyl-β-thienyl-L-alanyl-L-leucine.
Claim 4
Dependent Claim
9 words
The compound according to claim 1 which is L-tyrosylglycylglycyl-β-thienyl-L-alanyl-L-methionine.
References Cited (Backward Citations)
US3272790A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-29 | 1981-11-28 | 1982-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-29 | 1985-11-28 | 1986-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-29 | 1989-11-28 | 1990-05-30 | $7700.00 | Window Closed / Lapsed |