US4485045A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic phosphatidyl cholines useful in forming liposomes
Assignee: Research Corp
•
Filing: 1982-05-26
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Granted: 1984-11-27
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Expires: 2002-05-26
Abstract
Abstract Lower-ω-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the ω-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.
Inventors
- 👤 Steven L. Regen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1273; C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; C08; C08F; C08F30/00; C08F30/02; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2987; Y10T428/31504; Y10T428/31855; Y10T428/31909; Y10T428/31913
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
93 words
A compound of the structure ##STR7## B and C are each --CO--R 1 or --CO--R 2 ; in which --CO--R 1 is a fatty acid acyl group of at least 6 carbons, and --CO--R 2 is --CO--(CH 2 ) n --O--CO--CR 3 ═CHR 4 in which n is greater than 4, and R 3 and R 4 are each hydrogen or methyl; R 5 is hydrogen or --CH 2 --D, wherein D is --CO--R 2 and at least one of B, C, and D is present in the compound as --CO--R 2 .
Claim 2
Dependent Claim
93 words
A compound of the structure ##STR7## B and C are each --CO--R 1 or --CO--R 2 ; in which --CO--R 1 is a fatty acid acyl group of at least 6 carbons, and --CO--R 2 is --CO--(CH 2 ) n --O--CO--CR 3 ═CHR 4 in which n is greater than 4, and R 3 and R 4 are each hydrogen or methyl; R 5 is hydrogen or --CH 2 --D, wherein D is --CO--R 2 and at least one of B, C, and D is present in the compound as --CO--R 2 .
Claim 3
Dependent Claim
17 words
A compound of claim 1 in which B is --CO--R 1 and C is --CO--R 2 .
Claim 4
Dependent Claim
29 words
A compound of claim 2 in which --CO--R 1 is --CO--(CH 2 ) 15 --CH 3 and --CO--R 2 is --CO--(CH 2 ) 11 --O--CO--C(CH 3 )═CH 2 .
Claim 5
Dependent Claim
15 words
A compound of claim 1 in which B and C are both --CO--R 2 .
Claim 6
Dependent Claim
19 words
A compound of claim 4 in which --CO--R 2 is --CO--(CH 2 ) 11 --O--CO--C(CH 3 )═CH 2 .
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-27 | 1988-05-28 | 1988-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-27 | 1992-05-28 | 1992-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-27 | 1996-05-28 | 1996-11-27 | $7700.00 | Window Closed / Lapsed |