Patent US4478995A successfully refreshed from Google Patents.
US4478995A
Expired / Lapsed
US
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Complex compounds
Assignee: Teikoku Chemical Industry Co Ltd
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Filing: 1982-08-27
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Granted: 1984-10-23
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Expires: 2002-08-27
Abstract
Abstract A complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate and a cyclodextrin. The complex is useful for the treatment of ulcers.
Inventors
- 👤 Masamitu Shinoda
- 👤 Ikuo Tanaka
- 👤 Tadahiko Yasuda
- 👤 Isao Nakajima
- 👤 Tutomu Adachi
- 👤 Giichi Ikeda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 14:23
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/235; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61P; A61P35/00; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
13 words
A complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate with a cyclodextrin.
Claim 2
Dependent Claim
13 words
A complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate with a cyclodextrin.
Claim 3
Dependent Claim
34 words
The complex according to claim 1, wherein the acid addition salt is a member selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, carbonate, acetate, sulfate, p-toluenesulfonate, methanesulfonate, lactate, maleate, fumarate, tartarate, and citrate.
Claim 4
Dependent Claim
22 words
The complex according to claim 1, wherein the cyclodextrin is a member selected from the group consisting of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin.
Claim 5
Dependent Claim
15 words
The complex according to claim 1, which is obtained from (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride and β-cyclodextrin.
Claim 6
Dependent Claim
31 words
A pharmaceutical composition useful for treating ulcers, comprising as an active ingredient a complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate with a cyclodextrin, and a pharmaceutically acceptable carrier therefor.
Claim 7
Dependent Claim
31 words
A pharmaceutical composition useful for treating ulcers, comprising as an active ingredient a complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate with a cyclodextrin, and a pharmaceutically acceptable carrier therefor.
Claim 8
Dependent Claim
34 words
The composition according to claim 5, wherein the acid addition salt is a member selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, carbonate, acetate, sulfate, p-toluenesulfonate, methanesulfonate, lactate, maleate, fumarate, tartarate, and citrate.
Claim 9
Dependent Claim
22 words
The composition according to claim 5, wherein the cyclodextrin is a member selected from the group consisting of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin.
Claim 10
Dependent Claim
20 words
The composition according to claim 5, wherein the complex is formed by the reaction of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride and β-cyclodextrin.
References Cited (Backward Citations)
US3869443A
Cited
US4258180A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-23 | 1988-04-23 | 1988-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-23 | 1992-04-23 | 1992-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-23 | 1996-04-23 | 1996-10-23 | $7700.00 | Window Closed / Lapsed |