Ocular preparation housing steroid in two different therapeutic forms

Claim 1

A topically applied composition for treating inflammation of a warm-blooded animal afflicted with same, wherein the composition comprises: a pair consisting essentially of two topically acceptable different physical and chemical therapeutic forms of the same steroid, the pair selected from the group consisting essentially of prednisolone, prednisolone acetate, prednisolone trimethylacetate, prednisolone hemisuccinate, prednisolone phosphate, prednisolone valerate, prednisolone propionate, prednisolone butyrate, prednisolone phenylacetate, 16α-methyl-16α-fluoroprednisolone, 16α-methyl-6α-fluoroprednisolone acetate, 16α-methyl-6α-fluoroprednisolone disodium phosphate, prednisolone-21-N, N-dimethylglycinate, and prednisolone-21-N, N-diethylglycinate, said compositon containing from 0.01% to 10% of each therapeutic form of the same steroid comprising the pair, said pair comprising both forms present in a bioerodible polymeric polyorthoester topical carrier without any interactions, and wherein when the composition is administered topically, the composition administers the steriods by the polyorthoester bioeroding and administering the two different forms as a pair, for increasing the concentration of each steroid for topically, with the concentration of each steroid form topically applied being independent of the amount of the different steroid form topically applied from the polyorthoester for increasing the concentration of each steroid form available for passing into the tissues and steroid receptors of a warm-blooded animal in a therapeutically effective amount for treating inflammation over a prolonged period up to 600 hours.