Patent US4474770A successfully refreshed from Google Patents.
US4474770A
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Oligosaccharides having anti-Xa activity, pharmaceutical compositions containing them and method of use
Assignee: Choay SA
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Filing: 1983-08-22
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Granted: 1984-10-02
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Expires: 2003-08-22
Abstract
Abstract Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a U.S.P. titer in a ratio of at least 30. They consist of chains constituted by no more than 8 saccharidic moities. They possess a strong antithrombotic activity and are then useful as antithrombotic drugs.
Inventors
- 👤 Jean-Claude Lormeau
- 👤 Jean Choay
- 👤 Maurice Petitou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:04
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A; A61; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
101 words
An oligosaccharide fraction of the heparin chain which oligosaccharide which has improved antithrombotic activity in vivo (as measured by the Yin-Wessler test) higher than that of heparin, which oligosaccharide fraction (1) comprises not more than 8 saccharide units, (2) of which one is an N-sulfate-D-glucosamine unit, (3) has anti-Xa activity (measured by the Yin-Wessler test) at least 10 times that of heparin, (4) specific affinity for AT III, (5) a ratio of Yin-Wessler titer to U.S.P. titer of at least 30 and (6) virtually no anticoagulant activity (as determined by the U.S.P. test) and, the biologically acceptable salts of said oligosaccharide.
Claim 2
Dependent Claim
101 words
An oligosaccharide fraction of the heparin chain which oligosaccharide which has improved antithrombotic activity in vivo (as measured by the Yin-Wessler test) higher than that of heparin, which oligosaccharide fraction (1) comprises not more than 8 saccharide units, (2) of which one is an N-sulfate-D-glucosamine unit, (3) has anti-Xa activity (measured by the Yin-Wessler test) at least 10 times that of heparin, (4) specific affinity for AT III, (5) a ratio of Yin-Wessler titer to U.S.P. titer of at least 30 and (6) virtually no anticoagulant activity (as determined by the U.S.P. test) and, the biologically acceptable salts of said oligosaccharide.
Claim 3
Dependent Claim
37 words
A therapeutic antithrombotic composition which has antithrombotic activity (as measured by the Yin-Wessler test) higher than that of heparin which composition comprises a therapeutically acceptable carrier and in a therapeutically effective amount, an oligosaccharide of claim 1.
Claim 4
Dependent Claim
25 words
A therapeutic method for controlling thrombosis in a patient which comprises administering to said patient the therapeutic antithrombotic composition of claim 2 and controlling thrombosis.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-02 | 1988-04-02 | 1988-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-02 | 1992-04-02 | 1992-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-02 | 1996-04-02 | 1996-10-02 | $7700.00 | Window Closed / Lapsed |