Patent US4473569A successfully refreshed from Google Patents.
US4473569A
Expired / Lapsed
US
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Protective composition for users of cyanoacrylate adhesives
Assignee: Individual
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Filing: 1982-11-10
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Granted: 1984-09-25
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Expires: 2002-11-10
Abstract
Abstract A protective composition is provided for application to the skin (especially the hands) of persons working with cyanoacrylate adhesive compositions ("superglues" ), to prevent accidental adhesion of skin to skin or to other substrates. The composition comprises a skin-compatible adhesion-inhibiting substance for cyanoacrylate monomers, the substance being incorporated in a conventional topical pharmaceutical base to produce, e.g., a skin cream. Any cyanoacrylate monomer-stabilizer which is kind to the skin can be used, but in addition a group of named zwitterionic aminosulfonic acids ("ZASA's") is proposed and preferred for the purpose. They have a preferred pKa at in the range of 6.0-8.3 at 20 DEG C.
Inventors
- 👤 Donncha O'Sullivan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:30
CPC Classifications
A; A61; A61Q; A61Q17/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K8/466; A61K8/49; A61K8/494
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
58 words
An adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3 and said protective composition being in the form of a cream, solid or lotion.
Claim 2
Dependent Claim
58 words
An adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3 and said protective composition being in the form of a cream, solid or lotion.
Claim 3
Dependent Claim
40 words
A protective composition as in claim 1, wherein the compound is a member selected from the group consisting of 2-(N-Morpholinyl)-ethane sulfonic acid, N,N-bis-(2-Hydroxyethyl)-2-aminoethane sulfonic acid, 2[N-(N'-2-Hydroxyethyl)-piperazinyl] ethane sulfonic acid, 3-[N-(N'-2-Hydroxyethyl)-piperazinyl] propane sulfonic acid, Piperazine-1,4-bis-(2-ethane sulfonic acid), and 2-[N-tris-(Hydroxymethyl)-methylamino]-ethane sulfonic acid.
Claim 4
Dependent Claim
26 words
A protective composition as in claim 1, wherein said compound is present in an amount of from 0.05% to about 30% by weight of the composition.
Claim 5
Dependent Claim
25 words
A protective composition as in claim 3, wherein said compound is present in an amount of from 0.05% to 5% by weight of the composition.
Claim 6
Dependent Claim
25 words
A protective composition as in claim 3, wherein said compound is present in an amount of from 0.1% to 1.0% by weight of the composition.
Claim 7
Dependent Claim
15 words
A protective composition as recited in claim 1, wherein said compound is 2-[N-(N'-2-Hydroxyethyl)-piperazinyl]-ethane sulfonic acid.
Claim 8
Dependent Claim
35 words
A protective composition as in claim 2, wherein the selected Zwitterionic aminosulfonic acid compounds in said composition are 2-[N-(N'-2-Hydroxyethyl)-piperazinyl]-ethane sulfonic acid and 3-[N-(N'-2-Hydroxyethyl)-piperazinyl]-propane sulfonic acid, in a weight ratio of about 1 to 10, respectively.
Claim 9
Dependent Claim
16 words
A protective composition as in claim 1, which is in the form of a hand cream.
Claim 10
Dependent Claim
16 words
A protective composition as in claim 2, which is in the form of a hand cream.
Claim 11
Dependent Claim
24 words
A protective composition as in claim 1, wherein said composition is in the form of a lotion or stick for application to the skin.
Claim 12
Dependent Claim
24 words
A protective composition as in claim 2, wherein said composition is in the form of a lotion or stick for application to the skin.
Claim 13
Dependent Claim
73 words
An applicator material selected from the group consisting of papers, woven fabric pieces, non-woven fabric pieces and pads, impregnated with an adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises, incorporated in a dermatologically compatible base for topical application, an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3.
Claim 14
Dependent Claim
73 words
An applicator material selected from the group consisting of papers, woven fabric pieces, non-woven fabric pieces and pads, impregnated with an adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises, incorporated in a dermatologically compatible base for topical application, an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3.
Claim 15
Dependent Claim
43 words
An applicator material as in claim 12, wherein said Zwitterionic aminosulfonic acid compound is a member selected from the group consisting of 2-(N-Morpholinyl)-ethane sulfonic acid, N,N-bis-(2-Hydroxyethyl)-2-aminoethane sulfonic acid, 2-[N-(N'-2-Hydroxyethyl)-piperazinyl] ethane sulfonic acid, 3-[N-(N'-2-Hydroxyethyl)-piperazinyl] propane sulfonic acid, Piperazine-1,4-bis-(2-ethane sulfonic acid), and 2-[N-tris-(Hydroxymethyl)-methylamino]-ethane sulfonic acid.
Claim 16
Independent Claim
98 words
A method of protecting the skin of a person, working with a cyanoacrylate adhesive, against tissue adhesion, which method comprises applying to said person's skin, before skin contamination with said adhesive has occurred, or can occur, an effective adhesion-inhibiting protective amount of a coating of an adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises, incorporated in a dermatologically compatible base for topical application, an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3.
Claim 17
Independent Claim
98 words
A method of protecting the skin of a person, working with a cyanoacrylate adhesive, against tissue adhesion, which method comprises applying to said person's skin, before skin contamination with said adhesive has occurred, or can occur, an effective adhesion-inhibiting protective amount of a coating of an adhesion-inhibiting protective composition for the skin of a person working with cyanoacrylate-type adhesives, which composition comprises, incorporated in a dermatologically compatible base for topical application, an adhesion-inhibiting protective amount of at least one Zwitterionic aminosulfonic acid compound, said compound having a pK a value at 20° C. in the range of 6.0-8.3.
Claim 18
Dependent Claim
39 words
A method as in claim 14, wherein said compound is a member selected from the group consisting of 2-(N-Morpholinyl)-ethane sulfonic acid, N,N-bis-(2-Hydroxyethyl)-2-aminoethane sulfonic acid, 2-[N-(N'-2-Hydroxyethyl)-piperazinyl] ethane sulfonic acid, 3-[N-(N'-2-Hydroxyethyl)-piperazinyl] propane sulfonic acid, Piperazine-1,4-bis-(2-ethane sulfonic acid), and 2-[N-tris-(Hydroxymethyl)-methylamino]-ethane sulfonic acid.
Claim 19
Dependent Claim
13 words
A method as in claim 14, wherein said compound is 2-[N-(N'-2-Hydroxyethyl)-piperazinyl]-ethane sulfonic acid.
Claim 20
Dependent Claim
28 words
A method as in claim 15, wherein the selected compounds are 2-[N-(N'-2-Hydroxyethyl)-piperazinyl]-ethane sulfonic acid and 3-[N-(N'-2-Hydroxyethyl)-piperazinyl]-propane sulfonic acid, in a weight ratio of about 1 to 10, respectively.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-25 | 1988-03-26 | 1988-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-25 | 1992-03-26 | 1992-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-25 | 1996-03-26 | 1996-09-25 | $7700.00 | Window Closed / Lapsed |