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US4473544A
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Radio-iodine-labelled omega phenyl fatty acids
Assignee: Individual
•
Filing: 1982-07-14
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Granted: 1984-09-25
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Expires: 2002-07-14
Abstract
Abstract Radio-iodine-labelled omega-phenyl fatty acid of the formula: ##STR1## in which: X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen or an alkyl or alkoxy group having 1 or 2 carbon atoms; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion; and I is a radioactive iodine-123 or iodine-131 isotope which may be in the ortho- or para-position of the benzene nucleus, a process for the preparation of these radio-iodine-labelled phenyl fatty acids, and products containing them for scintigraphic examination of various organs of the body such as the heart and the liver.
Inventors
- 👤 Hans-Jurgen Machulla
- 👤 Manfred Marsmann
- 👤 Klaus Dutschka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:50
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/58; C07C59/64; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0402; C07C57/00; C07C57/52; C07C57/58; A61K2123/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
60 words
A radio-iodine-labelled ω-phenyl fatty acid of the formula: ##STR3## wherein X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion, and I is a radioactive iodine-123 or iodine 131 isotope which may be in ortho- or para-position of the benzene nucelus.
Claim 2
Dependent Claim
60 words
A radio-iodine-labelled ω-phenyl fatty acid of the formula: ##STR3## wherein X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion, and I is a radioactive iodine-123 or iodine 131 isotope which may be in ortho- or para-position of the benzene nucelus.
Claim 3
Dependent Claim
13 words
The radio-iodine labelled omega-phenyl fatty acid of claim 1 wherein Y is hydrogen.
Claim 4
Dependent Claim
16 words
The radio-labelled omega fatty acid of claim 2 wherein said acid is p-I 123 -omega-phenyl-pentadecanoic acid.
Claim 5
Independent Claim
73 words
A method of imaging organs of the body comprising intravenously injecting an effective amount of a composition comprising a compound of the formula: ##STR4## wherein X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion; and I is a radioactive iodine-123 or iodine-131-isotope which may be in ortho- or para-position of the benzene nucleus.
Claim 6
Independent Claim
73 words
A method of imaging organs of the body comprising intravenously injecting an effective amount of a composition comprising a compound of the formula: ##STR4## wherein X is an alkylene group having from 6 to 20 carbon atoms; R is hydrogen; Y is hydrogen, an alkali metal ion, alkaline earth metal ion or ammonium ion; and I is a radioactive iodine-123 or iodine-131-isotope which may be in ortho- or para-position of the benzene nucleus.
Claim 7
Dependent Claim
11 words
The method of claim 4 wherein said organ is the liver.
Claim 8
Dependent Claim
11 words
The method of claim 4 wherein said organ is the heart.
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein said compound is p-I 123 -omega-phenyl-decanoic.
Claim 10
Dependent Claim
11 words
The method of claim 7 wherein said organ is the heart.
Claim 11
Dependent Claim
11 words
The method of claim 7 wherein said organ is the liver.
Claim 12
Dependent Claim
13 words
The fatty acid of claim 1 wherein I is in the para position.
Claim 13
Dependent Claim
9 words
The method of claim 4 wherein Y is hydrogen.
Claim 14
Dependent Claim
12 words
The method of claim 11 wherein I is in the para position.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-25 | 1988-03-26 | 1988-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-25 | 1992-03-26 | 1992-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-25 | 1996-03-26 | 1996-09-25 | $7700.00 | Window Closed / Lapsed |