US4323547A
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Labeled fatty acids and method of making and using same
Assignee: Forschungszentrum Jülich
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Filing: 1979-06-28
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Granted: 1982-04-06
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Expires: 1999-06-28
Abstract
Abstract Radioactive-halogen labeled fatty acids, especially fatty acids having as an omega -terminal or mid-chain substituent 18F as the labeling atom. The hydrocarbon has more than fifteen carbon atoms in the hydrocarbon chain and is purified by high pressure liquid chromatography for use in investigating the kinetics of material exchange in the heart muscle.
Inventors
- 👤 Ernst J. Knust
- 👤 Christiane Kupfernagel
- 👤 Gerhard Stocklin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 19:13
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0404; A61K51/0406; A61K51/0402; A61K2123/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
45 words
An 18 F labeled fatty acid, particularly for investigation into the kinetics of heart muscle metabolism containing at least one positron-emitting 18 F atom at the ω terminal or at least at one position along the chain substantially central of the α and ω terminals.
Claim 2
Dependent Claim
45 words
An 18 F labeled fatty acid, particularly for investigation into the kinetics of heart muscle metabolism containing at least one positron-emitting 18 F atom at the ω terminal or at least at one position along the chain substantially central of the α and ω terminals.
Claim 3
Dependent Claim
20 words
An 18 F labeled fatty acid defined in claim 1 having 10 to 20 carbon atoms in the carbon chain.
Claim 4
Dependent Claim
20 words
The 18 F labeled fatty acid defined in claim 2 which is unsaturated and has at least 15 carbon atoms.
Claim 5
Dependent Claim
18 words
The 18 F labeled fatty acid defined in claim 2 which has 16, 17 or 18 carbon atoms.
Claim 6
Dependent Claim
31 words
In a method of investigating heart muscle metabolism by a noninvasive process, the improvement which comprises administering to the subject an 18 F labeled fatty acid as defined in claim 1.
Claim 7
Dependent Claim
27 words
The improvement defined in claim 5 wherein the 18 F labeled fatty acid is subjected to high pressure liquid chromatographic purification prior to administration to the subject.
Claim 8
Dependent Claim
20 words
The improvement defined in claim 6 wherein the 18 F labeled fatty acid has an uneven number of carbon atoms.
Claim 9
Dependent Claim
37 words
The improvement defined in claim 4 wherein the 18 F labeled fatty acid is selected from the group which consists of 16- 18 F hexanoic acid, 17- 18 F heptadecanoic acid and (9,10)- 18 F stearic acids.
Claim 10
Dependent Claim
43 words
A method of making the compound defined in claim 1 which comprises the steps of reacting potassium fluoride containing 18 F and an ester of the analogous brominated fatty acid in halogen exchange to produce a reaction product, and hydrolyzing the reaction product.
Claim 11
Dependent Claim
16 words
The method defined in claim 9 wherein the reaction is carried out in water free acetamide.
Claim 12
Dependent Claim
27 words
The method defined in claim 9 wherein the potassium fluoride is produced by treating KF with 18 F containing ester and evaporating the resulting mixture to dryness.
Claim 13
Dependent Claim
23 words
The method defined in claim 11, further comprising the step of purifying the 18 F labeled fatty acid by high pressure liquid chromatography.
Claim 14
Dependent Claim
17 words
A composition of matter for noninvasive investigation of heart-muscle metabolism processes, comprising the product of claim 12.
Claim 15
Dependent Claim
34 words
The composition defined in claim 13 wherein the 18 F labeled fatty acid is selected from the group which consists of 16- 18 F-palmitic acid, 17- 18 F-heptadecanoic acid and (9/10)- 18 F-stearic acids.
Claim 16
Dependent Claim
27 words
The composition defined in claim 13 or claim 14 which further comprises a human serum albumin solution as a vehicle for said 18 F labeled fatty acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-05 | 1985-10-05 | 1986-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-05 | 1989-10-05 | 1990-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-05 | 1993-10-05 | 1994-04-06 | $7700.00 | Window Closed / Lapsed |