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US4460684A
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Ascorbate-resistant broad range glucose test composition, test device and method
Assignee: Bayer Corp
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Filing: 1982-08-02
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Granted: 1984-07-17
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Expires: 2002-08-02
Abstract
Abstract A composition, test device and method for detecting the presence and/or determining concentration of glucose in a liquid test sample are disclosed. The composition is capable of determining glucose concentration over a broad range, e.g. 0 to about 5,000 milligrams (mg) of glucose per deciliter (dl) of test sample. Moreover, the composition is resistant to interference from the presence of ascorbate in the sample. The composition comprises glucose oxidase, peroxidase and, as an indicator capable of producing a detectable response in the presence of peroxidase and H2O2, a mixture of two compounds. One has the structure <IMAGE> and the other has the structure <IMAGE> in which R, same of different, is H or lower alkyl, R' is aryl and R'' is lower alkyl.
Inventors
- 👤 Robert Bauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:25
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/54; C12Q1/26; C12Q1/28; C12Q2326/00; C12Q2326/50; C12Q2326/90; C12Q2326/96; Y; Y10; Y10S; Y10S435/00; Y10S435/805; Y10S436/00; Y10S436/904
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
122 words
A composition for detecting the presence of glucose, determining the concentration of glucose, or both, in a test sample, whereby the composition is capable of determining concentration over a range of 0 to about 5000 milligrams of glucose per deciliter of test sample, and whereby the composition is resistant to interference from the presence of ascorbate in the sample, the composition comprising glucose oxidase, peroxidase and, as an indicator capable of producing a detectable response in the presence of peroxidase and H 2 O 2 , a mixture of two compounds, one having the structure ##STR6## and the other having the structure ##STR7## in which R, same or different is H or lower alkyl, R' is aryl and R" is lower alkyl.
Claim 2
Dependent Claim
122 words
A composition for detecting the presence of glucose, determining the concentration of glucose, or both, in a test sample, whereby the composition is capable of determining concentration over a range of 0 to about 5000 milligrams of glucose per deciliter of test sample, and whereby the composition is resistant to interference from the presence of ascorbate in the sample, the composition comprising glucose oxidase, peroxidase and, as an indicator capable of producing a detectable response in the presence of peroxidase and H 2 O 2 , a mixture of two compounds, one having the structure ##STR6## and the other having the structure ##STR7## in which R, same or different is H or lower alkyl, R' is aryl and R" is lower alkyl.
Claim 3
Dependent Claim
13 words
The composition of claim 1 in which the compounds are 4-aminoantipyrine and 4-methylcatechol.
Claim 4
Dependent Claim
30 words
A test device for detecting the presence and/or determining the concentration of glucose in a test sample comprising a carrier matrix incorporated with the composition of claim 1 or 2.
Claim 5
Dependent Claim
13 words
The test device of claim 3 in which the carrier matrix is paper.
Claim 6
Dependent Claim
33 words
A method for detecting the presence and/or determining the concentration of glucose in a test sample comprising contacting the sample with the composition of claim 1 or 2, and observing a detectable response.
Claim 7
Dependent Claim
32 words
A method for detecting the presence and/or determining the concentration of glucose in a test sample comprising contacting the sample with the test device of claim 3 and observing a detectable response.
Claim 8
Dependent Claim
32 words
A method for detecting the presence and/or determining the concentration of glucose in a test sample comprising contacting the sample with the test device of claim 4 and observing a detectable response.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-17 | 1988-01-16 | 1988-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-17 | 1992-01-16 | 1992-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-17 | 1996-01-16 | 1996-07-17 | $7700.00 | Window Closed / Lapsed |