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US4459289A
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Copolymers having bactericidal activity, process for the preparation thereof and pharmaceutical compositions therefrom
Assignee: TEXCONTOR - ANSTALT
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Filing: 1982-01-04
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Granted: 1984-07-10
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Expires: 2002-01-04
Abstract
Abstract Copolymers of formula I are described <IMAGE> (I) in which A is the monomeric unit of a natural or synthetic polymer, m is the degree of polymerization; m and n are different one from the other, and m is a number between about 300 and about 10,000 and n is a number between about 100 and about 250; R is a quaternary ammonium radical; X- is an anion. A may be the monomeric unit of starch or the monomeric unit of hydroxyethylcellulose. The substances exhibit substantial activity in the treatment of infections of the skin and mucosa and fungus infections and in general, high bactericidal activity accompanied by low toxicity.
Inventors
- 👤 Javier E. Maltz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61P; A61P3/00; A61P3/06; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; Y; Y10; Y10S; Y10S424/00; Y10S424/02; Y10S424/04
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
193 words
The method of treatment of a patient affected by infections of the skin of the type of pyrodermia, streptodermia, staphylodermia, acne, cutaneous mycosis, moniliasis, ulcerative gingivitis, sycosis barbae and ringworm of the feet; which consists of applying to the area of the patient affected by said infections of the skin a composition containing 0.1-5% of a compound of formula I ##STR5## wherein A is the starch or hydroxyethylcellulose unit, m is the degree of polymerization; m and n are different one from the other, and m is a number between about 300 and about 10,000 and n is a number between about 100 and about 250; R is a quaternary ammonium radical which is a member selected from the group consisting of formulae (a), (b), (c) and (d) ##STR6## in which R', R", R"', are the same or are different one from the other and are alkyl or benzyl radicals and p is an integral number between 0 and 10; X - is the anion Cl - , Br - , I - , F - or HSO 4 - ; together with conventional carriers or excipients for creams, ointments, lotions and powders.
Claim 2
Independent Claim
193 words
The method of treatment of a patient affected by infections of the skin of the type of pyrodermia, streptodermia, staphylodermia, acne, cutaneous mycosis, moniliasis, ulcerative gingivitis, sycosis barbae and ringworm of the feet; which consists of applying to the area of the patient affected by said infections of the skin a composition containing 0.1-5% of a compound of formula I ##STR5## wherein A is the starch or hydroxyethylcellulose unit, m is the degree of polymerization; m and n are different one from the other, and m is a number between about 300 and about 10,000 and n is a number between about 100 and about 250; R is a quaternary ammonium radical which is a member selected from the group consisting of formulae (a), (b), (c) and (d) ##STR6## in which R', R", R"', are the same or are different one from the other and are alkyl or benzyl radicals and p is an integral number between 0 and 10; X - is the anion Cl - , Br - , I - , F - or HSO 4 - ; together with conventional carriers or excipients for creams, ointments, lotions and powders.
Claim 3
Dependent Claim
21 words
The method, according to claim 1, wherein A is maize starch or hydroxyethylcellulose and R is ##STR7## wherein R' is ethyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-10 | 1988-01-09 | 1988-07-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-10 | 1992-01-09 | 1992-07-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-10 | 1996-01-09 | 1996-07-10 | $7700.00 | Window Closed / Lapsed |