US4035146A
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Binding of antimicrobial compounds to a hydroxyl containing substrate with cyanuric chloride
Assignee: JE SIEBEL SONS' COMPANY Inc A CORP OF
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Filing: 1975-10-20
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Granted: 1977-07-12
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Expires: 1995-10-20
Abstract
Abstract Methods and compositions are disclosed for chemically bonding an antimicrobial compound to an hydroxyl bearing substrate such as cellulose, starches or leather. Cyanuric chloride (2, 4, 6 tri-chloro 1, 3, 5 triazine) is bonded to the substrate through the substrate hydroxyl and to the antimicrobial through an amine, guanido or quaternary ammonium group. The composition is: <IMAGE> R1 or R2 may be chlorine or the same or different amine, guanido or quaternary ammonium containing antimicrobial. The bonding process is carried out in an aqueous solution having a pH of about 9 - 10.
Inventors
- 👤 Mortimer Wilkes Brenner
- 👤 Louis Laufer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:33
CPC Classifications
C; C14; C14C; C14C1/00; C14C1/02
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
128 words
The method of bonding an amine, guanido or quaternary ammonium containing antimicrobial compound selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, alkyl dimethyl benzyl ammonium chloride, trimethyl octyl decyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride and mixtures thereof to a hydroxyl containing substrate taken from the group consisting of cellulose, starches and leather comprising the steps of: A. reacting the substrate with cyanuric chloride in a solution to chemically bond the cyanuric chloride to the substrate; B. and then reacting an effective amount of antimicrobial in solution with the cyanuric chloride on the substrate to chemically bond the cyanuric chloride to the antimicrobial, said cyanuric chloride being present in an amount effective to bond the antimicrobial to the substrate through the cyanuric chloride.
Claim 2
Independent Claim
128 words
The method of bonding an amine, guanido or quaternary ammonium containing antimicrobial compound selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, alkyl dimethyl benzyl ammonium chloride, trimethyl octyl decyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride and mixtures thereof to a hydroxyl containing substrate taken from the group consisting of cellulose, starches and leather comprising the steps of: A. reacting the substrate with cyanuric chloride in a solution to chemically bond the cyanuric chloride to the substrate; B. and then reacting an effective amount of antimicrobial in solution with the cyanuric chloride on the substrate to chemically bond the cyanuric chloride to the antimicrobial, said cyanuric chloride being present in an amount effective to bond the antimicrobial to the substrate through the cyanuric chloride.
Claim 3
Dependent Claim
37 words
The method of bonding an amine, quanido or quaternary ammonium containing antimicrobial substance to a hydroxyl containing substrate as defined in claim 1 wherein the solution is alkaline and has a pH of from 9 to 10.
Claim 4
Dependent Claim
71 words
An antimicrobial composition comprising a hydroxyl containing substrate to which is bound cyanuric chloride and one or more amine, guanido or quaternary ammonium containing antimicrobial compounds selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, trimethyl octyl decyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride, and mixtures thereof, said antimicrobial compound being chemically bonded to the hydroxyl containing substrate through the cyanuric chloride.
Claim 5
Dependent Claim
71 words
An antimicrobial composition comprising a hydroxyl containing substrate to which is bound cyanuric chloride and one or more amine, guanido or quaternary ammonium containing antimicrobial compounds selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, trimethyl octyl decyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride, and mixtures thereof, said antimicrobial compound being chemically bonded to the hydroxyl containing substrate through the cyanuric chloride.
Claim 6
Dependent Claim
23 words
The antimicrobial composition defined in claim 3 wherein said hydroxyl containing substrate is selected from the group consisting of cellulose, starches and leather.
Claim 7
Dependent Claim
104 words
A persistent antimicrobial composition comprising a cellulose substrate having chemically bound thereto a cyanuric chloride radical and one or more amine, guanido or quaternary ammonium containing antimicrobial radicals chemically bound to said cyanuric chloride radical to provide a composition of the formula ##STR4## wherein X is the substrate, R 1 or R 2 may be chlorine, and one or each of R 1 and R 2 is an antimicrobial radical, either the same or different, selected from the group consisting of chlorhexidine acetate, streptomycin, trimethyl octyl decyl ammonium chloride, bacitracin, tetracycline hydrochloride, neomycin sulfate, alkyldimethyl benzyl ammonium chloride and cetyl dimethyl benzyl ammonium chloride.
Claim 8
Dependent Claim
104 words
A persistent antimicrobial composition comprising a cellulose substrate having chemically bound thereto a cyanuric chloride radical and one or more amine, guanido or quaternary ammonium containing antimicrobial radicals chemically bound to said cyanuric chloride radical to provide a composition of the formula ##STR4## wherein X is the substrate, R 1 or R 2 may be chlorine, and one or each of R 1 and R 2 is an antimicrobial radical, either the same or different, selected from the group consisting of chlorhexidine acetate, streptomycin, trimethyl octyl decyl ammonium chloride, bacitracin, tetracycline hydrochloride, neomycin sulfate, alkyldimethyl benzyl ammonium chloride and cetyl dimethyl benzyl ammonium chloride.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-11 | 1981-01-10 | 1981-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-11 | 1985-01-10 | 1985-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-11 | 1989-01-10 | 1989-07-12 | $7700.00 | Window Closed / Lapsed |