Patent US4454116A successfully refreshed from Google Patents.
US4454116A
Expired / Lapsed
US
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Immunization of humans against enterotoxogenic infection by Escherichia coli
Assignee: Bactex Inc
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Filing: 1980-09-15
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Granted: 1984-06-12
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Expires: 2000-09-15
Abstract
Abstract There is provided a vaccine material capable of providing substantial levels of protection against human disease caused by infection with Escherichia coli. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or to a pregnant or lactating female where protection of the newborn is desired.
Inventors
- 👤 Charles C. Brinton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:47
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/025; A61K39/0258; C; C07; C07K; C07K14/00; C07K14/195; C07K14/24; C07K14/245; C07K16/00; C07K16/12; C07K16/1203; C07K16/1228; C07K16/1232; A61K2039/545; A61K2039/55; A61K2039/552; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S424/00; Y10S424/825; Y10S435/00; Y10S435/82
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
144 words
A method of protecting human subjects against colibacillosis caused by a member of a predetermined first group of strains of piliated E. coli which comprises administering to a subject in need of protection a composition capable of raising the antibody level of a human subject to a level sufficient to provide protection against infection caused by a member of a first group of strains of piliated E.coli comprising pili previously separated from other E.coli organism components derived from at least one member selected from a second group consisting of strains of piliated E. coli organisms having Type 1 pili and those having NMS pili wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said group.
Claim 2
Independent Claim
144 words
A method of protecting human subjects against colibacillosis caused by a member of a predetermined first group of strains of piliated E. coli which comprises administering to a subject in need of protection a composition capable of raising the antibody level of a human subject to a level sufficient to provide protection against infection caused by a member of a first group of strains of piliated E.coli comprising pili previously separated from other E.coli organism components derived from at least one member selected from a second group consisting of strains of piliated E. coli organisms having Type 1 pili and those having NMS pili wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said group.
Claim 3
Dependent Claim
26 words
A method of claim 1 wherein the vaccine composition is administered at least once to the subjects between about 5 and about 60 days before infection.
Claim 4
Dependent Claim
23 words
A method of claim 2 wherein there is administered between 1 and 100 μg/Kg body weight of the pilic component of vaccine composition.
Claim 5
Dependent Claim
35 words
A method of claim 1 wherein the pilic component of the vaccine composition is derived from Type 1 pili or NMS pili of E. coli H 10407 (ATCC 31705) or E. coli E-25 (ATCC 31703).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |