Patent US4354833A successfully refreshed from Google Patents.
Patent US4453941A successfully refreshed from Google Patents.
US4453941A
Expired / Lapsed
US
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Composition and process for producing pigmentation in hair or skin
Assignee: Goshen College
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Filing: 1982-11-08
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Granted: 1984-06-12
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Expires: 2002-11-08
Abstract
Abstract A composition and process for producing pigmentation in hair and skin is disclosed which employs non-mutagenic compounds to duplicate naturally occurring biosynthetic colors. The composition for imparting golden coloration comprises as active ingredients a solution of a tyrosine derivative having a side chain with a substituted amine group in admixture with certain compounds having a reactive nitrogen moiety, and is topically applied in the presence of an oxidant. The composition for imparting a dark coloration comprises as active ingredients a solution of tyrosine derivative having a side chain free for indole formation in admixture with certain compounds having a reactive nitrogen moiety, and is topically applied in the presence of an oxidant. Mixtures of the two compositions may be applied to impart proportionate intermediate colors.
Inventors
- 👤 Merle E. Jacobs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 09:21
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/445; A61Q5/00; A61Q5/10
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
63 words
A composition for coloring hair or skin comprising: (a) an effective amount of a tyrosyl derivative having a side chain free for indolization, (b) an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and (c) an effective amount of an oxidant for imparting a rich, dark color to hair or skin.
Claim 2
Dependent Claim
63 words
A composition for coloring hair or skin comprising: (a) an effective amount of a tyrosyl derivative having a side chain free for indolization, (b) an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and (c) an effective amount of an oxidant for imparting a rich, dark color to hair or skin.
Claim 3
Dependent Claim
72 words
A coloring composition for imparting a rich, dark color to hair or skin comprising: (a) an effective amount of a tyrosyl derivative selected from the group consisting of DOPA and dopamine, (b) an effective amount of an omega-amino acid selected from the group consisting of beta-alanine, lysine, gamma-amino-butyric acid, beta-amino-isobutyric acid and beta-aminopropionitrile, and (c) an effective amount of an oxidant for imparting said rich, dark color to said hair or skin.
Claim 4
Dependent Claim
72 words
A coloring composition for imparting a rich, dark color to hair or skin comprising: (a) an effective amount of a tyrosyl derivative selected from the group consisting of DOPA and dopamine, (b) an effective amount of an omega-amino acid selected from the group consisting of beta-alanine, lysine, gamma-amino-butyric acid, beta-amino-isobutyric acid and beta-aminopropionitrile, and (c) an effective amount of an oxidant for imparting said rich, dark color to said hair or skin.
Claim 5
Dependent Claim
47 words
A coloring composition for imparting a rich, dark color to hair or skin comprising, on a ratio basis: (a) about one one-hundredth of a mole of DOPA, (b) about one tenth of a mole of beta-alanine, and (c) about one tenth of a mole of copper chloride.
Claim 6
Dependent Claim
47 words
A coloring composition for imparting a rich, dark color to hair or skin comprising, on a ratio basis: (a) about one one-hundredth of a mole of DOPA, (b) about one tenth of a mole of beta-alanine, and (c) about one tenth of a mole of copper chloride.
Claim 7
Dependent Claim
47 words
A coloring composition for imparting a rich, dark color to hair or skin comprising, on a ratio basis: (a) about one one-hundredth of a mole of dopamine, (b) about one tenth of a mole of beta-alanine, and (c) about one tenth of a mole of copper chloride.
Claim 8
Dependent Claim
47 words
A coloring composition for imparting a rich, dark color to hair or skin comprising, on a ratio basis: (a) about one one-hundredth of a mole of dopamine, (b) about one tenth of a mole of beta-alanine, and (c) about one tenth of a mole of copper chloride.
Claim 9
Independent Claim
98 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing an effective amount of a tyrosyl derivative having a side chain free for indolization, an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and an effective amount of an oxidant to produce an admixture capable of imparting said rich, dark color to said hair or skin: and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 10
Independent Claim
98 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing an effective amount of a tyrosyl derivative having a side chain free for indolization, an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and an effective amount of an oxidant to produce an admixture capable of imparting said rich, dark color to said hair or skin: and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 11
Dependent Claim
38 words
The method of claim 5 wherein: said tyrosyl derivative is selected from the group consisting of DOPA and dopamine, and said omega-amino acid is selected from the group consisting of beta-alanine, lysine, gamma-aminobutyric acid, beta-aminoisobutyric acid and beta-aminopropionitrile.
Claim 12
Independent Claim
86 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of dopamine, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said rich, dark color to said hair or skin; and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 13
Independent Claim
86 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of dopamine, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said rich, dark color to said hair or skin; and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 14
Independent Claim
86 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of DOPA, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said rich, dark color to said hair or skin; and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 15
Independent Claim
86 words
A method for imparting a rich, dark color to hair or skin comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of DOPA, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said rich, dark color to said hair or skin; and (2) contacting said hair or skin with an effective amount of said admixture to impart said rich, dark color to said hair or skin.
Claim 16
Dependent Claim
85 words
A composition for coloring hair or skin comprising: (a) an effective amount of a first tyrosyl derivative having a side chain not free for indolization, (b) an effective amount of a second tyrosyl derivative having a side chain free for indolization, (c) an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and (d) an effective amount of an oxidant for imparting proportionally darker color to hair or skin relative to a natural color.
Claim 17
Dependent Claim
85 words
A composition for coloring hair or skin comprising: (a) an effective amount of a first tyrosyl derivative having a side chain not free for indolization, (b) an effective amount of a second tyrosyl derivative having a side chain free for indolization, (c) an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and (d) an effective amount of an oxidant for imparting proportionally darker color to hair or skin relative to a natural color.
Claim 18
Dependent Claim
99 words
A coloring composition for imparting proportionately darker color to hair or skin relative to a natural color, comprising: (a) an effective amount of a first tyrosyl derivative selected from the group consisting of N-acetyldopamine and leucyl-tyrosine, (b) an effective amount of a second tyrosyl derivative selected from the group consisting of DOPA and dopamine, (c) an effective amount of an omega-amino acid selected from the group consisting of beta-alanine, lysine, gamma-amino-butyric acid, beta-aminoisobutyric acid and beta-aminopropionitrile, and (d) an effective amount of an oxidant for imparting said proportionately darker color to hair or skin relative to said natural color.
Claim 19
Dependent Claim
99 words
A coloring composition for imparting proportionately darker color to hair or skin relative to a natural color, comprising: (a) an effective amount of a first tyrosyl derivative selected from the group consisting of N-acetyldopamine and leucyl-tyrosine, (b) an effective amount of a second tyrosyl derivative selected from the group consisting of DOPA and dopamine, (c) an effective amount of an omega-amino acid selected from the group consisting of beta-alanine, lysine, gamma-amino-butyric acid, beta-aminoisobutyric acid and beta-aminopropionitrile, and (d) an effective amount of an oxidant for imparting said proportionately darker color to hair or skin relative to said natural color.
Claim 20
Dependent Claim
73 words
A coloring composition for imparting a proportionately darker color to hair or skin relative to a natural color, comprising, on a ratio basis: (a) about one one-hundredth of a mole of N-acetyldopamine, (b) an effective amount of dopamine, (c) about one tenth of a mole of beta-alanine, and (d) about one tenth of a mole of copper chloride, for imparting said proportionately darker color to hair or skin relative to said natural color.
Claim 21
Dependent Claim
73 words
A coloring composition for imparting a proportionately darker color to hair or skin relative to a natural color, comprising, on a ratio basis: (a) about one one-hundredth of a mole of N-acetyldopamine, (b) an effective amount of dopamine, (c) about one tenth of a mole of beta-alanine, and (d) about one tenth of a mole of copper chloride, for imparting said proportionately darker color to hair or skin relative to said natural color.
Claim 22
Independent Claim
120 words
A method for imparting a proportionately darker color to hair or skin relative to a natural color, comprising: (1) admixing an effective amount of a first tyrosyl derivative having a side chain not free for indolization, an effective amount of a second tyrosyl derivative having a side chain free for indolization, an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and an effective amount of an oxidant to produce an admixture capable of imparting said proportionately darker color to said hair or skin relative to said natural color; and (2) contacting said hair or skin with an effective amount of said admixture to impart said proportionately darker color.
Claim 23
Independent Claim
120 words
A method for imparting a proportionately darker color to hair or skin relative to a natural color, comprising: (1) admixing an effective amount of a first tyrosyl derivative having a side chain not free for indolization, an effective amount of a second tyrosyl derivative having a side chain free for indolization, an effective amount of an omega-amino acid having an aliphatic structure which includes from about three to about six carbon atoms, and an effective amount of an oxidant to produce an admixture capable of imparting said proportionately darker color to said hair or skin relative to said natural color; and (2) contacting said hair or skin with an effective amount of said admixture to impart said proportionately darker color.
Claim 24
Dependent Claim
53 words
The method of claim 12 wherein: said first tyrosyl derivative is selected from the group consisting of N-acetyldopamine and leucyl-tyrosine, said second tyrosyl derivative is selected from the group consisting of DOPA and dopamine, and said omega-amino acid is selected from the group consisting of beta-alanine, lysine, gamma-aminobutyric acid, beta-aminoisobutyric acid and beta-aminopropionitrile.
Claim 25
Independent Claim
96 words
A method for imparting a proportionately darker color to hair or skin relative to a natural color, comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of N-acetyldopamine, an effective amount of dopamine, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said proportionately darker color to said hair or skin relative to said natural color; and (2) contacting said hair or skin with an effective amount of said admixture to impart said proportionately darker color.
Claim 26
Independent Claim
96 words
A method for imparting a proportionately darker color to hair or skin relative to a natural color, comprising: (1) admixing, on a ratio basis, about one one-hundredth of a mole of N-acetyldopamine, an effective amount of dopamine, about one tenth of a mole of beta-alanine, and about one tenth of a mole of copper chloride to produce an admixture capable of imparting said proportionately darker color to said hair or skin relative to said natural color; and (2) contacting said hair or skin with an effective amount of said admixture to impart said proportionately darker color.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |