US4021538A
Expired / Lapsed
US
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Method for producing pigmentation in hair or skin
Assignee: Individual
•
Filing: 1975-09-29
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Granted: 1977-05-03
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Expires: 1995-09-29
Abstract
Abstract A composition and method for producing pigmentation in skin or hair by topical application is described. The composition comprises as active ingredients one or more esters of DOPA wherein the esterifying radical is an alkyl, aryl or alkylene radical having up to 12 carbon atoms, or methyl dopate. The pigmentation producing ester is dissolved in a pharmaceutically acceptable vehicle which may be alkaline, neutral or acidic, and may contain peroxides or other oxidizing agents. Skin treated by topical application of the composition of this invention has been found to be protected against sun burn and against erythema from ultraviolet light in proportion to the extent of the pigmentation produced.
Inventors
- 👤 Ruey J. Yu
- 👤 Eugene J. Van Scott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:45
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61Q5/00; A61Q5/06; A61Q5/065
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
67 words
A method for producing pigmentation in hair or skin comprising: topically applying to preselected areas of the body, a composition comprising an effective pigmentation producing amount of at least one DOPA ester selected from the group consisting of esters having the formula ##STR2## wherein R is an alkyl, aryl or alkylene radical having from 1 to 12 carbon atoms, and methyl dopate in a pharmaceutically acceptable vehicle.
Claim 2
Independent Claim
67 words
A method for producing pigmentation in hair or skin comprising: topically applying to preselected areas of the body, a composition comprising an effective pigmentation producing amount of at least one DOPA ester selected from the group consisting of esters having the formula ##STR2## wherein R is an alkyl, aryl or alkylene radical having from 1 to 12 carbon atoms, and methyl dopate in a pharmaceutically acceptable vehicle.
Claim 3
Dependent Claim
32 words
The method of claim 1 wherein R is a member selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, iso-butyl, sec-butyl, n-amyl, iso-amyl, glycerol, propylene glycol, benzyl, lauryl, and cyclohexyl.
Claim 4
Dependent Claim
21 words
The method of claim 2 wherein said ester is present in said composition in from 0.1 to 10 percent by weight.
Claim 5
Dependent Claim
57 words
The method of claim 3 wherein said vehicle comprises an alkaline solvent selected from the group consisting of ammonium hydroxide, sodium bicarbonate, sodium carbonate, sodium hydroxide, sodium methoxide, sodium ethoxide, sodium borate, sodium phosphate, potassium bicarbonate, potassium carbonate, potassium hydroxide, potassium methoxide, potassium ethoxide, potassium borate, potassium phosphate, monoethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, ethylenediamine, isopropanolamine and tetraethanolammonium hydroxide.
Claim 6
Dependent Claim
23 words
The method of claim 4 wherein the vehicle further comprises ethyl alcohol present in up to 95 percent by volume of the solvent.
Claim 7
Dependent Claim
22 words
The method of claim 4 wherein the vehicle further comprises water present in up to 95 percent by volume of the solvent.
Claim 8
Dependent Claim
17 words
The method of claim 4 wherein the solvent has an initial pH of from 8 to 10.
Claim 9
Dependent Claim
19 words
The method claim 4 further comprising neutralizing said composition to a pH of from 5-6 before topical application thereof.
Claim 10
Dependent Claim
36 words
The method of claim 3 wherein said vehicle comprises an aqueous solution of an acid selected from the group consisting of HCl, H 2 SO 4 , and HNO 3 at a pH of from 3-6.
Claim 11
Dependent Claim
43 words
The method of claim 3 wherein said vehicle comprises a solution of an acid selected from the group consisting of HCl, H 2 SO 4 and HNO 3 in ethyl alcohol, said alcohol present in up to 95% of said composition, by volume.
Claim 12
Dependent Claim
10 words
The method of claim 1 wherein said vehicle is water.
Claim 13
Dependent Claim
60 words
The method of claim 1 in which said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 14
Dependent Claim
59 words
The method of claim 5 wherein said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 15
Dependent Claim
59 words
The method of claim 6 wherein said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 16
Dependent Claim
59 words
The method of claim 9 wherein said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 17
Dependent Claim
59 words
The method of claim 10 wherein said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 18
Dependent Claim
59 words
The method of claim 11 wherein said vehicle further comprises an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite, present in from 0.1 to 1% by weight of said composition.
Claim 19
Dependent Claim
33 words
The method of claim 9 further comprising subsequently topically applying a buffered alkaline solution selected from the group consisting of tyrosine-KOH, glycine-NaOH, and aspartic acid-NaOH having a pH of from 3 to 11.
Claim 20
Dependent Claim
33 words
The method of claim 10 further comprising subsequently topically applying a buffered alkaline solution selected from the group consisting of tyrosine-KOH, glycine-NaOH, and aspartic acid-NaOH having a pH of from 3 to 11.
Claim 21
Dependent Claim
33 words
The method of claim 11 further comprising subsequently topically applying a buffered alkaline solution selected from the group consisting of tyrosine-KOH, glycine-NaOH, and aspartic acid-NaOH having a pH of from 3 to 11.
Claim 22
Dependent Claim
68 words
The method of claim 9 further comprising subsequently topically applying an alkaline solution selected from the group consisting of ammonium hydroxide, sodium bicarbonate, sodium carbonate, sodium hydroxide, sodium methoxide, sodium ethoxide, sodium borate, sodium phosphate, potassium bicarbonate, potassium carbonate, potassium hydroxide, potassium methoxide, potassium ethoxide, potassium borate, potassium phosphate, monoethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, ethylenediamine, isopropanolamine and tetraethanolammonium hydroxide said solution having a pH of from 6 to 11.
Claim 23
Dependent Claim
68 words
The method of claim 10 further comprising subsequently topically applying an alkaline solution selected from the group consisting of ammonium hydroxide, sodium bicarbonate, sodium carbonate, sodium hydroxide, sodium methoxide, sodium ethoxide, sodium borate, sodium phosphate, potassium bicarbonate, potassium carbonate, potassium hydroxide, potassium methoxide, potassium ethoxide, potassium borate, potassium phosphate, monoethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, ethylenediamine, isopropanolamine and tetraethanolammonium hydroxide said solution having a pH of from 6 to 11.
Claim 24
Dependent Claim
68 words
The method of claim 11 further comprising subsequently topically applying an alkaline solution selected from the group consisting of ammonium hydroxide, sodium bicarbonate, sodium carbonate, sodium hydroxide, sodium methoxide, sodium ethoxide, sodium borate, sodium phosphate, potassium bicarbonate, potassium carbonate, potassium hydroxide, potassium methoxide, potassium ethoxide, potassium borate, potassium phosphate, monoethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, ethylenediamine, isopropanolamine and tetraethanolammonium hydroxide said solution having a pH of from 6 to 11.
Claim 25
Dependent Claim
62 words
The method of claim 9 further comprising subsequently applying topically a solution containing an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite present in from 0.1 to 1% by weight of said solution.
Claim 26
Dependent Claim
62 words
The method of claim 10 further comprising subsequently applying topically a solution containing an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite present in from 0.1 to 1% by weight of said solution.
Claim 27
Dependent Claim
62 words
The method of claim 11 further comprising subsequently applying topically a solution containing an oxidizing agent selected from the group consisting of benzoyl peroxide, perbenzoic acid, peracetic acid, hydrogen peroxide, ammonium persulfate, potassium persulfate, potassium chromate, potassium dichromate, potassium permanganate, periodic acid, sodium periodate, osmium tetroxide, sodium hypochlorite and calcium hypochlorite present in from 0.1 to 1% by weight of said solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-02 | 1980-11-01 | 1981-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-02 | 1984-11-01 | 1985-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-02 | 1988-11-01 | 1989-05-03 | $7700.00 | Window Closed / Lapsed |