Patent US4448730A successfully refreshed from Google Patents.
US4448730A
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US
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Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors
Assignee: Individual
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Filing: 1982-04-20
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Granted: 1984-05-15
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Expires: 2002-04-20
Abstract
Abstract Di, tri and tetrahydroxybenzohydroxamic acids, amides and the corresponding di, tri and tetrahydroxy substituted phenylalkanohydroxamic acids, amides and phenyl esters, ribonucleotide reductase inhibitors.
Inventors
- 👤 Bartholomeus van't Riet
- 👤 Howard L. Elford
- 👤 Galen L. Wampler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
99 words
A method of inhibiting ribonucleotide reductase which comprises administering to a mammal carrying a tumor having a relatively high ribonucleotide reductase level, an amount of a compound according to the following formula effective to inhibit ribonucleotide reductase ##STR4## wherein n is 2, 3 or 4, m is 1, 2 or 3 and R 1 is NH 2 , NHOH, NH(C 1 -C 3 )alkyl, N[(C 1 -C 3 )alkyl] 2 , aryl-NH 2 or O-phenyl except that when n is 2 or 3, m is 0 and R 1 is NHOH, no OH can be ortho to the carboxyl.
Claim 2
Independent Claim
99 words
A method of inhibiting ribonucleotide reductase which comprises administering to a mammal carrying a tumor having a relatively high ribonucleotide reductase level, an amount of a compound according to the following formula effective to inhibit ribonucleotide reductase ##STR4## wherein n is 2, 3 or 4, m is 1, 2 or 3 and R 1 is NH 2 , NHOH, NH(C 1 -C 3 )alkyl, N[(C 1 -C 3 )alkyl] 2 , aryl-NH 2 or O-phenyl except that when n is 2 or 3, m is 0 and R 1 is NHOH, no OH can be ortho to the carboxyl.
Claim 3
Dependent Claim
19 words
A method according to claim 1 in which two of the OH groups in the phenyl ring are vicinal.
Claim 4
Dependent Claim
12 words
A method according to claim 1 in which R 1 is NHOH.
Claim 5
Dependent Claim
26 words
A compound of the formula ##STR5## in which n is 2 or 3, m' is 1, 2 or 3 and R 1 is NHOH, or o-phenyl.
Claim 6
Dependent Claim
26 words
A compound of the formula ##STR5## in which n is 2 or 3, m' is 1, 2 or 3 and R 1 is NHOH, or o-phenyl.
Claim 7
Dependent Claim
11 words
A compound according to claim 4, said compound being 3,4-dihydroxyphenylacetohydroxamic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-15 | 1987-11-14 | 1988-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-15 | 1991-11-14 | 1992-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-15 | 1995-11-14 | 1996-05-15 | $7700.00 | Window Closed / Lapsed |