US4263322A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxy benzohydroxamic acids and benzamides
Assignee: Individual
•
Filing: 1979-03-01
•
Granted: 1981-04-21
•
Expires: 1999-03-01
Abstract
Abstract Di or trihydroxybenzohydroxamic acids or N-substituted benzamides, inhibitors or ribonucleotide reductase.
Inventors
- 👤 Bartholomeus van't Riet
- 👤 Howard L. Elford
- 👤 Galen L. Wampler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
88 words
A method of inhibiting ribonucleotide reductase which comprises administering to a mammal carrying a tumor having a relatively high ribonucleotide reductase level, an amount of a compound according to the following formula effective to inhibit ribonucleotide reductase ##STR4## wherein R 3 and R 4 are H or OH and R 1 is NH 2 or NHOH such that, when R 1 is NH 2 , R 3 is H and R 4 OH and when R 1 is NHOH, R 3 is OH and R 4 is H.
Claim 2
Independent Claim
88 words
A method of inhibiting ribonucleotide reductase which comprises administering to a mammal carrying a tumor having a relatively high ribonucleotide reductase level, an amount of a compound according to the following formula effective to inhibit ribonucleotide reductase ##STR4## wherein R 3 and R 4 are H or OH and R 1 is NH 2 or NHOH such that, when R 1 is NH 2 , R 3 is H and R 4 OH and when R 1 is NHOH, R 3 is OH and R 4 is H.
Claim 3
Dependent Claim
11 words
A method according to claim 1 in which 3,4,5-trihydroxybenzamide is administered.
Claim 4
Dependent Claim
15 words
A method according to claim 1 in which 2,3,4-trihydroxybenzohydroxamic acid is the active inhibitory drug.
References Cited (Backward Citations)
US2849480A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-20 | 1984-10-20 | 1985-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-20 | 1988-10-20 | 1989-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-20 | 1992-10-20 | 1993-04-21 | $7700.00 | Window Closed / Lapsed |