US4434788A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enhancer of anti-tumor effect
Assignee: Yamasa Shoyu KK
•
Filing: 1981-07-27
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Granted: 1984-03-06
•
Expires: 2001-07-27
Abstract
Abstract A nucleoside selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine enhances, when administered to a tumor-bearing animal under an anti-tumor treatment, the anti-tumor effect due to the anti-tumor treatment. The anti-tumor treatment comprises irradiation of a tumor site of the animal or administration of an anti-tumor agent to the animal.
Inventors
- 👤 Shigekazu Nakatsugawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P35/00; A61P43/00; C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/16
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
33 words
A method of enhancement of anti-tumor effect which comprises administering to a tumor-bearing animal under an anti-tumor treatment an enhancer or the anti-tumor effect selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine.
Claim 2
Independent Claim
33 words
A method of enhancement of anti-tumor effect which comprises administering to a tumor-bearing animal under an anti-tumor treatment an enhancer or the anti-tumor effect selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine.
Claim 3
Dependent Claim
41 words
The method of enhancement of anti-tumor effect as claimed in claim 1 in which the anti-tumor treatment comprises irradiation of a tumor site of the animal and the enhancer is administered to the animal before, simultaneously with or after the irradiation.
Claim 4
Dependent Claim
29 words
The method of enhancement of anti-tumor effect as claimed in claim 2 in which the enhancer is administered to the animal before the animal is subjected to the irradiation.
Claim 5
Dependent Claim
30 words
The method of enhancement of anti-tumor effect as claimed in claim 2 in which the enhancer is administered to the animal after the animal has been subjected to the irradiation.
Claim 6
Dependent Claim
48 words
The method of enhancement of anti-tumor effect as claimed in claim 1 in which the anti-tumor treatment comprises administration to the animal of an anti-tumor agent to the animal and the enhancer is administered to the animal before, simultaneously with or after the administration of the anti-tumor agent.
Claim 7
Dependent Claim
30 words
The method of enhancement of anti-tumor effect as claimed in claim 5 in which the anti-tumor agent is selected from the group consisting of anti-metabolites, anti-tumor antibiotics and alkylating agents.
Claim 8
Dependent Claim
37 words
In a method of treating tumor in a tumor-bearing animal, the improvement which comprises administering to a tumor-bearing animal under the anti-tumor treatment an enhancer of anti-tumor effect selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine.
Claim 9
Dependent Claim
37 words
In a method of treating tumor in a tumor-bearing animal, the improvement which comprises administering to a tumor-bearing animal under the anti-tumor treatment an enhancer of anti-tumor effect selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine.
Claim 10
Dependent Claim
39 words
The method of treating tumor as claimed in claim 7 in which the anti-tumor treatment comprises irradiation of a tumor site of the animal and the enhancer is administered to the animal before, simultaneously with or after the irradiation.
Claim 11
Dependent Claim
22 words
The method of treating tumor as claimed in claim 8 in which the enhancer is administered to the animal before the irradiation.
Claim 12
Dependent Claim
19 words
The method of treating tumor as claimed in claim 8 in which the enhancer is administered after the irradiation.
Claim 13
Dependent Claim
40 words
The method of treating tumor as claimed in claim 7 in which the anti-tumor treatment comprises administration to the animal of an anti-tumor agent and the enhancer is administered before, simultaneously with or after the administration of the anti-tumor agent.
Claim 14
Dependent Claim
28 words
The method of treating tumor as claimed in claim 11 in which the anti-tumor agent is selected from the group consisting of anti-metabolites, anti-tumor antibiotics and alkylating agents.
References Cited (Backward Citations)
US3915958A
Cited
US3919193A
Cited
US4056674A
Cited
US4141972A
Cited
US4056673A
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US4177348A
Cited
US4297347A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-06 | 1987-09-05 | 1988-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-06 | 1991-09-05 | 1992-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-06 | 1995-09-05 | 1996-03-06 | $7700.00 | Window Closed / Lapsed |