US4056674A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of 3-deazaguanine
Assignee: Viratek Inc
•
Filing: 1975-06-05
•
Granted: 1977-11-01
•
Expires: 1995-06-05
Abstract
Abstract Ribofuranosyl derivatives of 3-deazaguanine including the 5'-phosphate, 3',5'-cyclic phosphate and 5'-deoxy, useful as antiviral agents and antibacterial agents, are disclosed.
Inventors
- 👤 Roland K. Robins
- 👤 Robert J. Rousseau
- 👤 Abdul M. Mian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:05
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/90
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
136 words
A compound of the structure ##STR7## wherein X is ##STR8## --NH 2 or --OCH 3 ; Y is ##STR9## or --C.tbd.N where R is H or acyl and R 1 is ═Ch--N(CH 3 ) 2 ; Z is β-D-ribofuranosyl, 5-deoxy-β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate, β-D-ribofuranosyl-3,5-cyclic phosphate, C 1 -C 18 acyl and isopropylidene β-D-ribofuranosyl, C 1 -C 18 acyl and isopropylidene 5-deoxy-β-D-ribofuranoxyl, C 1 -C 18 acyl and isopropylidene β-D-ribofuranosyl-5-phosphate or C 1 -C 18 β-D-ribofuranosyl-3,5-cyclic phosphate; and the physiologically acceptable salts thereof; with the proviso that X is ##STR10## only when X and Y are joined together; and X is --NH 2 or --OCH 3 and Y is --C.tbd.N only when X and Y are not joined together; and Z is not β-D-ribofuranosyl or C 1 -C 18 acyl β-D-ribofuranosyl when Y is ##STR11## where R is H.
Claim 2
Dependent Claim
136 words
A compound of the structure ##STR7## wherein X is ##STR8## --NH 2 or --OCH 3 ; Y is ##STR9## or --C.tbd.N where R is H or acyl and R 1 is ═Ch--N(CH 3 ) 2 ; Z is β-D-ribofuranosyl, 5-deoxy-β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate, β-D-ribofuranosyl-3,5-cyclic phosphate, C 1 -C 18 acyl and isopropylidene β-D-ribofuranosyl, C 1 -C 18 acyl and isopropylidene 5-deoxy-β-D-ribofuranoxyl, C 1 -C 18 acyl and isopropylidene β-D-ribofuranosyl-5-phosphate or C 1 -C 18 β-D-ribofuranosyl-3,5-cyclic phosphate; and the physiologically acceptable salts thereof; with the proviso that X is ##STR10## only when X and Y are joined together; and X is --NH 2 or --OCH 3 and Y is --C.tbd.N only when X and Y are not joined together; and Z is not β-D-ribofuranosyl or C 1 -C 18 acyl β-D-ribofuranosyl when Y is ##STR11## where R is H.
Claim 3
Dependent Claim
31 words
A compound of the structure ##STR12## wherein Z is 5-deoxy-β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate or β-D-ribofuranosyl-3,5-cyclic phosphate; and the C 1 -C 18 acyl, isopropylidene and dimethylaminomethylene derivatives and the physiologically acceptable salts, thereof.
Claim 4
Dependent Claim
31 words
A compound of the structure ##STR12## wherein Z is 5-deoxy-β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate or β-D-ribofuranosyl-3,5-cyclic phosphate; and the C 1 -C 18 acyl, isopropylidene and dimethylaminomethylene derivatives and the physiologically acceptable salts, thereof.
Claim 5
Dependent Claim
9 words
A compound of claim 2 wherein Z is β-D-ribofuranosyl-5-phosphate.
Claim 6
Dependent Claim
9 words
A compound of claim 2 wherein Z is 5-deoxy-β-D-ribofuranosyl.
Claim 7
Dependent Claim
10 words
A compound of claim 2 wherein Z is ribofuranosyl-3,5-cyclic phosphate.
Claim 8
Dependent Claim
54 words
A compound of claim 1 of the structure ##STR13## wherein X is --NH 2 or --OCH 3 ; Z is β-D-ribofuranosyl, 5-deoxy-β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate, β-D-ribofuranosyl-3,5-cyclic phosphate, C 1 -C 18 acyl and isopropylidene β-D-ribofuranosyl, C 1 -C 18 acyl and isopropylidene 5-deoxy-β-D-ribofuranosyl-5-phosphate and C 1-C 18 acyl ribofuranosyl-3,5-cyclic phosphate and the physiologically acceptable salts thereof.
Claim 9
Dependent Claim
14 words
A compound of claim 6 wherein X is NH 2 and Z is β-D-ribofuranosyl.
Claim 10
Dependent Claim
14 words
A compound of claim 6 wherein X is NH 2 and Z is β-D-ribofuranosyl-5-phosphate.
Claim 11
Dependent Claim
14 words
A compound of claim 6 wherein X is NH 2 and Z is β-D-ribofuranosyl-3,5-phosphate.
Claim 12
Dependent Claim
14 words
A compound of claim 6 wherein X is NH 2 and Z is 5-deoxy-β-D-ribofuranosyl.
Claim 13
Dependent Claim
32 words
A compound of claim 6 wherein X is OCH 3 and Z is β-D-ribofuranosyl, β-D-ribofuranosyl-5-phosphate, β-D-ribofuranosyl-3,5-cyclic phosphate, 5-deoxy-β-D-ribofuranosyl and C 1 -C 18 acyl and isopropylidene derivatives and physiologically acceptable salts thereof.
Claim 14
Dependent Claim
1 words
6-Amino-3-(5-phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
Claim 15
Dependent Claim
1 words
6-Amino-3-(5-phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
Claim 16
Dependent Claim
1 words
6-Amino-1-(5-phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
Claim 17
Dependent Claim
1 words
6-Amino-1-(5-phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
Claim 18
Dependent Claim
2 words
6-Amino-1-(3,5-cyclic phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
Claim 19
Dependent Claim
2 words
6-Amino-1-(3,5-cyclic phosphoryl-β-D-ribofuranosyl)imidazo[4,5-c]pyridin-4(5H)one.
References Cited (Backward Citations)
US3332935A
Cited
US3454559A
Cited
US3535207A
Cited
US3917583A
Cited
US3893998A
Cited
US3919193A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |