US3917583A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Substituted cyclic AMP derivatives
Assignee: Viratek Inc
•
Filing: 1973-02-07
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Granted: 1975-11-04
•
Expires: 1993-02-07
Abstract
Abstract 2-Substituted derivatives of cyclic AMP and a process of making the same are disclosed which are useful to inhibit the enzyme phosphodiesterase, to activate protein kinase and steriodogenesis, and as intermediates in the synthesis process.
Inventors
- 👤 Rich B Meyer
- 👤 Dennis A Shuman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:54
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/052; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
5 words
A COMPOUND OF THE STRUCTURE:
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE STRUCTURE:
Claim 3
Dependent Claim
17 words
The compound of claim 1 in which X is N, Z is NH2 and Y is CR1.
Claim 4
Dependent Claim
12 words
The compound of claim 1 in which R1 is C1 C6 alkyl.
Claim 5
Dependent Claim
13 words
The compound of claim 1 in which R2 is C1 to C6 alkyl.
Claim 6
Dependent Claim
12 words
The compound of claim 1 in which X and Y are N.
Claim 7
Dependent Claim
10 words
The compound of claim 5 in which Z is NH.
Claim 8
Dependent Claim
41 words
A process of synthesizing 2-substituted derivatives of cyclic AMP comprising condensing 5-amino-1- Beta -D-ribofuranosylimidazole-4-carboxamidine 3'',5''-cyclic phosphate with a carboxaldehyde selected from the group consisting of alkyl, aryl, aralkyl and pyridyl carboxaldehyde in refluxing alcohol to provide the corresponding 2-substituted adenine derivative.
Claim 9
Dependent Claim
41 words
A process of synthesizing 2-substituted derivatives of cyclic AMP comprising condensing 5-amino-1- Beta -D-ribofuranosylimidazole-4-carboxamidine 3'',5''-cyclic phosphate with a carboxaldehyde selected from the group consisting of alkyl, aryl, aralkyl and pyridyl carboxaldehyde in refluxing alcohol to provide the corresponding 2-substituted adenine derivative.
Claim 10
Dependent Claim
31 words
The process of claim 7 in which the carboxaldehyde is a C1 to C8 alkyl carboxaldehyde and condensation occurs in refluxing ethanol for from about 5 minutes to approximately 1 hour.
Claim 11
Dependent Claim
26 words
The process of claim 7 in which the carboxaldehyde is benzaldehyde and condensation occurs in refluxing ethanol for from about 5 minutes to about 1 hour.
Claim 12
Dependent Claim
26 words
The process of claim 7 in which the carboxaldehyde is pyridine-2-carboxaldehyde and condensation occurs in refluxing ethanol for from about 5 minutes to about 1 hour.
Claim 13
Dependent Claim
54 words
A process of synthesizing 2-substituted derivatives of cyclic AMP comprising condensing 5-amino-1- Beta -D-ribofuranosylimidazole-4-carboxamidine 3'' ,5''-cyclic phosphate with a carboxaldehyde selected from the group consisting of alkyl, aryl, aralkyl and pyridyl carboxaldehyde in an aqueous organic water-miscible solvent, and reacting such condensation product with a dehydrogenation reagent to provide the corresponding 2-substituted adenine derivative.
Claim 14
Dependent Claim
54 words
A process of synthesizing 2-substituted derivatives of cyclic AMP comprising condensing 5-amino-1- Beta -D-ribofuranosylimidazole-4-carboxamidine 3'' ,5''-cyclic phosphate with a carboxaldehyde selected from the group consisting of alkyl, aryl, aralkyl and pyridyl carboxaldehyde in an aqueous organic water-miscible solvent, and reacting such condensation product with a dehydrogenation reagent to provide the corresponding 2-substituted adenine derivative.
References Cited (Backward Citations)
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US3337528A
Cited
US3364199A
Cited
US3450693A
Cited
US3712885A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |