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US4432750A
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Additive sterol solution and method for preserving normal red cell morphology in whole blood during storage
Assignee: Baxter International Inc
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Filing: 1981-12-02
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Granted: 1984-02-21
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Expires: 2001-12-02
Abstract
Abstract An additive solution is used to preserve normal red blood cell morphology during storage. The solution comprises a concentration of a nontoxic, physiologically compatible sterol, such as cholesterol, epi-cholesterol, lanosterol, stigmasterol, ergosterol, desmosterol, fucosterol, cholestanol, epi-cholestanol, coprosterol, epi-coprosterol, lathosterol, or campesterol. The sterol is present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood.
Inventors
- 👤 Timothy N. Estep
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:30
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/18
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
38 words
An additive solution for preserving normal red blood cell morphology during whole blood storage, said solution comprising a physiologically blood compatible sterol present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood.
Claim 2
Dependent Claim
38 words
An additive solution for preserving normal red blood cell morphology during whole blood storage, said solution comprising a physiologically blood compatible sterol present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood.
Claim 3
Dependent Claim
12 words
An additive solution according to claim 1 wherein said sterol is cholesterol.
Claim 4
Dependent Claim
17 words
An additive solution according to claim 1 wherein said sterol is in the form of an emulsion.
Claim 5
Dependent Claim
17 words
An additive solution according to claim 1 and further including, as part of said solution, an anticoagulant.
Claim 6
Dependent Claim
21 words
An additive solution according to claim 4 and further including, as part of said solution, a nutrient for the whole blood.
Claim 7
Dependent Claim
27 words
An additive solution according to claim 1 wherein said sterol is present in a concentration of between approximately 2.0 and 3.0 milligrams per milliliter of whole blood.
Claim 8
Dependent Claim
50 words
A whole blood storage system comprising a container having an interior for receiving whole blood for storage, a solution carried within said interior and including a physiologically blood compatible sterol present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood stored within said container.
Claim 9
Dependent Claim
50 words
A whole blood storage system comprising a container having an interior for receiving whole blood for storage, a solution carried within said interior and including a physiologically blood compatible sterol present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood stored within said container.
Claim 10
Dependent Claim
29 words
A whole blood storage system according to claim 7 wherein said sterol is present in a concentration of between approximately 2.0 and 3.0 milligrams per milliliter of whole blood.
Claim 11
Dependent Claim
16 words
A whole blood storage system according to claim 7 or 8 wherein said sterol is cholesterol.
Claim 12
Dependent Claim
21 words
A whole blood storage system according to claim 7 or 8 wherein said sterol is in the form of an emulsion.
Claim 13
Dependent Claim
22 words
A whole blood storage system according to claim 7 or 8 wherein said solution further includes, as a part thereof, an anticoagulant.
Claim 14
Dependent Claim
24 words
A whole blood storage system according to claim 11 wherein said solution further includes, as a part thereof, a nutrient for the whole blood.
Claim 15
Dependent Claim
42 words
A whole blood storage system according to claim 12 wherein said container includes a donor tube having an end attached in flow communication with said interior and an opposite end, and a phlebotomy needle attached in flow communication with said opposite end.
Claim 16
Independent Claim
45 words
A method for storing whole blood so as to preserve normal red blood cell morphology during the storage period, said method comprising the step of introducing for each milliliter of whole blood present between approximately 1.0 and 3.0 milligrams of a physiologically blood compatible sterol.
Claim 17
Independent Claim
45 words
A method for storing whole blood so as to preserve normal red blood cell morphology during the storage period, said method comprising the step of introducing for each milliliter of whole blood present between approximately 1.0 and 3.0 milligrams of a physiologically blood compatible sterol.
Claim 18
Dependent Claim
21 words
A method according to claim 14 and further including, prior to said sterol introduction step, the step of emulsifying the sterol.
Claim 19
Dependent Claim
22 words
A method according to claim 14 wherein said sterol introduction step includes introducing the sterol at the outset of the storage period.
Claim 20
Dependent Claim
12 words
A method according to claim 14 wherein the sterol utilized is cholesterol.
Claim 21
Dependent Claim
34 words
A method according to claim 14 wherein said sterol introduction step includes the step of introducing, for each milliliter of whole blood, between approximately 2.0 and 3.0 milligrams of a physiologically blood compatible sterol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |