US4222379A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multiple blood bag having plasticizer-free portions and a high blood component survival rate
Assignee: Baxter International Inc
•
Filing: 1978-10-26
•
Granted: 1980-09-16
•
Expires: 1998-10-26
Abstract
Abstract A multiple blood bag system comprising a donor bag for receiving blood from a donor, and one or more transfer bags, communicating by flexible tubing with the donor bag, for receiving a blood component from the donor bag. In accordance with this invention, the various bags may be made of differing materials to provide differing characteristics to the bags as desired. For example, the transfer bag or bags may be made of a translucent, flexible, sterilizable material which is free of blood extractable ester-type plasticizers, and may have a relatively high carbon dioxide diffusion capacity. The donor bag may be made of a translucent, flexible, sterilizable material which contains preferably at least five percent by weight of a specified ester plasticizer, sufficient to cause a substantial reduction in plasma hemoglobin produced by blood stored under normal conditions for 21 days in the donor bag, when compared with blood in a corresponding, plasticizer-free donor bag stored under equivalent conditions.
Inventors
- 👤 Dale A. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:28
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/10
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
102 words
In a multiple blood bag system which comprises a first bag, a second bag, and conduit means providing sealed flow communication between said first bag and second bag in which said first bag is made of a plastic material which comprises a different polymer entity from that of said second bag, one of said bags being equipped with a blood collection tube, and the polymer entity of the the first bag exhibiting the characteristic of suppressing hemolysis of blood cells on long term storage, whereby the first bag and second bag exhibit differing physical characteristics which are selectively beneficial to their functions.
Claim 2
Dependent Claim
102 words
In a multiple blood bag system which comprises a first bag, a second bag, and conduit means providing sealed flow communication between said first bag and second bag in which said first bag is made of a plastic material which comprises a different polymer entity from that of said second bag, one of said bags being equipped with a blood collection tube, and the polymer entity of the the first bag exhibiting the characteristic of suppressing hemolysis of blood cells on long term storage, whereby the first bag and second bag exhibit differing physical characteristics which are selectively beneficial to their functions.
Claim 3
Dependent Claim
57 words
The multiple bag blood system of claim 1 in which a second transfer bag is present, being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers and exhibits a higher carbon dioxide diffusion characteristic than the other bags in the system whereby the pH of the platelets stored therein is resistant to reduction.
Claim 4
Dependent Claim
49 words
The multiple bag system of claim 1 in which said first bag is a donor bag for receiving whole blood from a donor, said blood collection tube being connected to the first bag, said second bag comprising a transfer bag for receiving a blood component from the donor bag.
Claim 5
Dependent Claim
41 words
The multiple bag system of claim 1 in which said first bag contains an amount of liquid plasticizer sufficient to suppress the amount of plasma hemoglobin produced by blood stored therein, when compared with a corresponding bag free of said plasticizer.
Claim 6
Dependent Claim
45 words
The multiple bag system of claim 1 in which said first bag contains an amount of an ester-type material which is sufficient to suppress the amount of plasma hemoglobin produced by blood stored therein, when compared with a corresponding bag free of said ester-type material.
Claim 7
Dependent Claim
50 words
The multiple bag system of claim 1 in which said first bag contains an ester-type plasticizer in a concentration sufficient to cause a reduction in the plasma hemoglobin content of blood stored in said bag for 21 days, when compared with a corresponding bag which is free of said material.
Claim 8
Dependent Claim
87 words
In a multiple blood bag system which comprises a first bag, a second bag, and conduit means providing sealed flow communication between said first and second bags, the improvement comprising: said second bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said first bag being made of a translucent, flexible, sterilizable material which contains an amount of liquid plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates sufficient to suppress the amount of plasma hemoglobin produced by blood stored therein.
Claim 9
Dependent Claim
87 words
In a multiple blood bag system which comprises a first bag, a second bag, and conduit means providing sealed flow communication between said first and second bags, the improvement comprising: said second bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said first bag being made of a translucent, flexible, sterilizable material which contains an amount of liquid plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates sufficient to suppress the amount of plasma hemoglobin produced by blood stored therein.
Claim 10
Dependent Claim
97 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains from 5 to 50 percent by weight of a di-ester selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 11
Dependent Claim
97 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains from 5 to 50 percent by weight of a di-ester selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 12
Dependent Claim
15 words
The blood bag system of claim 8 in which said liquid plasticizer is a diethylhexylphthalate.
Claim 13
Dependent Claim
97 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material, which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains from 5 to 50 percent by weight of a diester selected from the group consisting of di-2-ethylhexylphthalate and di-2-ethylhexyladipate.
Claim 14
Dependent Claim
97 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material, which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains from 5 to 50 percent by weight of a diester selected from the group consisting of di-2-ethylhexylphthalate and di-2-ethylhexyladipate.
Claim 15
Dependent Claim
87 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a transparent, flexible, autoclavable material which is free of blood-extractable plasticizers, said donor bag being made of a transparent, flexible, autoclavable material which contains from 15 to 50 percent by weight of di-2-ethylhexylphthalate.
Claim 16
Dependent Claim
87 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a transparent, flexible, autoclavable material which is free of blood-extractable plasticizers, said donor bag being made of a transparent, flexible, autoclavable material which contains from 15 to 50 percent by weight of di-2-ethylhexylphthalate.
Claim 17
Dependent Claim
19 words
The multiple blood bag system of claim 11 in which said transfer bag is made of a polyolefin material.
Claim 18
Dependent Claim
19 words
The multiple blood bag system of claim 12 in which said donor bag is made of a polyester material.
Claim 19
Dependent Claim
26 words
The multiple blood bag system of claim 12 in which said donor bag is made of a formulation of polyvinyl chloride plasticized with said di-2-ethylhexyl phthalate.
Claim 20
Dependent Claim
24 words
The multiple blood bag system of claim 12 in which said donor bag contains from 15 to 40 percent by weight of di-2-ethylhexyl phthalate.
Claim 21
Dependent Claim
28 words
The multiple blood bag system of claim 12 in which said conduit means comprises flexible tubing made of the same translucent, flexible autoclavable material as the transfer bag.
Claim 22
Dependent Claim
28 words
The multiple blood bag system of claim 12 in which a plurality of transfer bags are present, being in communication through said conduit means with the donor bag.
Claim 23
Dependent Claim
124 words
The multiple blood bag system of claim 12 in which at least one of said transfer bags is made of a copolymer comprising from 10 to 40 percent by weight of a polyolefin consisting essentially of propylene units; from 40 to 85 percent by weight of a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1) a central block comprising 50 to 85 percent by weight of the copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units, and (2) terminal blocks of polystyrene; and from 0 to 40 percent by weight of a softening agent selected from the group consisting of polyethylene and poly(ethylene-vinyl acetate) containing no more than 35 percent by weight of vinyl acetate.
Claim 24
Dependent Claim
37 words
The multiple blood bag system of claim 18 in which a second transfer bag is present which is made of a flexible polyester material, and said donor bag is made of polyvinyl chloride plasticized with said di-2-ethylhexylphthalate.
Claim 25
Dependent Claim
36 words
The multiple blood bag system of claim 11 in which said transfer bag is made of a polyolefin material which exhibits a relatively high low-temperature strength, whereby the bag may be frozen for collection of cryoprecipitate.
Claim 26
Dependent Claim
120 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable polyolefin material which is free of blood-extractable plasticizers and exhibits a relatively high carbon dioxide diffusion characteristic whereby the pH of platelets stored therein is resistent to reduction, said donor bag being made of a translucent, flexible, sterilizable plastic material which contains from 15 to 50 percent by weight of a blood-extractable plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 27
Dependent Claim
120 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable polyolefin material which is free of blood-extractable plasticizers and exhibits a relatively high carbon dioxide diffusion characteristic whereby the pH of platelets stored therein is resistent to reduction, said donor bag being made of a translucent, flexible, sterilizable plastic material which contains from 15 to 50 percent by weight of a blood-extractable plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 28
Dependent Claim
15 words
The multiple blood bag system of claim 21 in which said extractable plasticizer is di-2-ethylhexylphthalate.
Claim 29
Dependent Claim
23 words
The multiple blood bag system of claim 22 in which said donor bag is made of a polyvinyl chloride formulation plasticized with di-2-ethylhexylphthalate.
Claim 30
Dependent Claim
91 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable, polyester material, free of ester-type blood extractable materials, said donor bag being made of a translucent, flexible, sterilizable, polyvinyl chloride plastic material which contains from 5 to 50 percent by weight of di-2-ethylhexylphthalate.
Claim 31
Dependent Claim
91 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable, polyester material, free of ester-type blood extractable materials, said donor bag being made of a translucent, flexible, sterilizable, polyvinyl chloride plastic material which contains from 5 to 50 percent by weight of di-2-ethylhexylphthalate.
Claim 32
Dependent Claim
111 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizer, said donor bag being made of a translucent, flexible, sterilizable plastic material, said donor bag containing in its interior an insert portion of plastic material which contains at least 5 percent by weight of a blood-extractable plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 33
Dependent Claim
111 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizer, said donor bag being made of a translucent, flexible, sterilizable plastic material, said donor bag containing in its interior an insert portion of plastic material which contains at least 5 percent by weight of a blood-extractable plasticizer selected from the group consisting of dioctylphthalates and dioctyladipates.
Claim 34
Dependent Claim
28 words
The multiple blood bag system of claim 25 in which 15 to 50 percent by weight of said blood extractable plasticizer is present in said interior plastic insert.
Claim 35
Dependent Claim
24 words
The multiple blood bag system of claim 26 in which the outer walls of said donor bag are essentially free of blood extractable plasticizers.
Claim 36
Dependent Claim
23 words
The multiple blood bag system of claim 26 in which said interior plastic insert comprises a polyvinyl chloride formulation containing a blood-extractable plasticizer.
Claim 37
Dependent Claim
123 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains sufficient amount of an ester material selected from the group consisting of dioctylphthalates and dioctyladipates to cause a reduction in the plasma hemoglobin content of blood stored in said bag for 21 days, when compared with a corresponding bag which is free of said material.
Claim 38
Dependent Claim
123 words
In a multiple blood bag system which comprises a donor bag for receiving blood from a donor, at least one transfer bag for receiving a blood component from said donor bag, and conduit means providing sealed, flow communication between said donor bag and transfer bag, the improvement comprising: said transfer bag being made of a translucent, flexible, sterilizable material which is free of blood-extractable plasticizers, said donor bag being made of a translucent, flexible, sterilizable material which contains sufficient amount of an ester material selected from the group consisting of dioctylphthalates and dioctyladipates to cause a reduction in the plasma hemoglobin content of blood stored in said bag for 21 days, when compared with a corresponding bag which is free of said material.
Claim 39
Dependent Claim
16 words
The blood bag system of claim 29 in which said ester material contains branched octyl radicals.
Claim 40
Dependent Claim
14 words
The blood bag system of claim 30 in which said ester material is di-2-ethylhexylphthalate.
Claim 41
Dependent Claim
19 words
The multiple blood bag system of claim 29 in which said transfer bag is made of a polyolefin material.
Claim 42
Dependent Claim
19 words
The multiple blood bag system of claim 32 in which said donor bag is made of a polyester material.
Claim 43
Dependent Claim
25 words
The multiple blood bag system of claim 33 in which said donor bag is made of a formulation of polyvinyl chloride plasticized with said di-2-ethylhexylphthalate.
Claim 44
Dependent Claim
28 words
The multiple blood bag system of claim 34 in which a plurality of transfer bags are present, being in communication through said conduit means with the donor bag.
Claim 45
Dependent Claim
124 words
The multiple blood bag system of claim 29 in which at least one of said transfer bags is made of a copolymer comprising from 10 to 40 percent by weight of a polyolefin consisting essentially of propylene units; from 40 to 85 percent by weight of a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1), a central block comprising 50 to 85 percent by weight of a copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units and (2) terminal blocks of polystyrene; and from 0 to 40 percent by weight of a softening agent selected of the group consisting of polyethylene and poly(ethylene-vinyl acetate) containing no more than 35 percent by weight of vinyl acetate.
Claim 46
Dependent Claim
35 words
The multiple bag system of claim 36 in which a second transfer bag is present which is made of a flexible polyester material, and said donor bag is made of polyvinyl chloride which contains di-2-ethylhexylphthalate.
References Cited (Backward Citations)
US3186961A
Cited
US3945380A
Cited
US3986506A
Cited
US3940802A
Cited
US4112089A
Cited
US4140162A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-16 | 1984-03-17 | 1984-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-16 | 1988-03-17 | 1988-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-16 | 1992-03-17 | 1992-09-16 | $7700.00 | Window Closed / Lapsed |