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US4428875A
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Compounds of dichlorodiethylaminophenylalanine with anti-tumor activity
Assignee: Proter SpA
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Filing: 1981-10-15
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Granted: 1984-01-31
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Expires: 2001-10-15
Abstract
Abstract Compounds with high anti-tumor activity and of moderate toxicity are described which are constituted by tripeptides formed from dichlorodiethylaminophenylalanine, para-fluorophenylalanine and methionine bonded together by peptide links. The tripeptides of the invention are particularly useful in the treatment of malignant tumors.
Inventors
- 👤 Augusto De Barbieri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:02
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0827; A; A61; A61P; A61P35/00; C07K5/06; C07K5/06008; C07K5/06078; C07K5/0802; C07K5/0812
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
14 words
Tripeptide formed from the aminoacids dichlorodiethylaminophenylalanine, para-fluorophenylalanine and methionine bonded together by CO-NH-peptide links.
Claim 2
Dependent Claim
14 words
Tripeptide formed from the aminoacids dichlorodiethylaminophenylalanine, para-fluorophenylalanine and methionine bonded together by CO-NH-peptide links.
Claim 3
Dependent Claim
14 words
Compound as claimed in claim 1, wherein each said aminoacid has a laevo-rotatory configuration.
Claim 4
Dependent Claim
21 words
Compound as claimed in claim 1, wherein said tripeptide comprises a dichlorodiethylaminophenylalanine bonded by peptide links to para-fluorophenylalanine and methionine respectively.
Claim 5
Dependent Claim
16 words
Compound as claimed in claim 1, selected from the esters and ester hydrochlorides of said tripeptides.
Claim 6
Dependent Claim
35 words
Compound as claimed in claim 1, wherein the terminal aminoacid in said tripeptide having an amine group not bonded in a peptide link is selected from para-fluorophenylalanine and methionine and said amine group is formylated.
Claim 7
Dependent Claim
6 words
The compound p-fluoro-L-phenylalanyl-m-di(2-chloroethyl)-amino-L-phenylalanyl-L-methionine ethyl ester hydrochloride.
Claim 8
Dependent Claim
6 words
The compound p-fluoro-L-phenylalanyl-m-di(2-chloroethyl)-amino-L-phenylalanyl-L-methionine ethyl ester hydrochloride.
References Cited (Backward Citations)
US4087520A
Cited
US4153688A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-30 | 1987-08-01 | 1988-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-30 | 1991-08-01 | 1992-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-30 | 1995-08-01 | 1996-01-31 | $7700.00 | Window Closed / Lapsed |