US4087520A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lowering blood pressure with new L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptides
Assignee: Roche Diagnostics GmbH
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Filing: 1976-03-09
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Granted: 1978-05-02
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Expires: 1996-03-09
Abstract
Abstract An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula <IMAGE> wherein A is an alkylene radical which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, and R is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical, OR A PHARMACOLOGICALLY COMPATIBLE SALT THEREOF. These compounds are outstanding in lowering blood pressure.
Inventors
- 👤 Franz Braun
- 👤 Kurt Stach, deceased
- 👤 executor by Werner Plattner
- 👤 Max Thiel
- 👤 Gisbert Sponer
- 👤 Karl Dietmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:51
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07K5/06078; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
63 words
An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula ##STR4## wherein A is an alkylene radical having up to 5 carbon atoms which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, and R is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical, or a pharmacologically compatible salt thereof.
Claim 2
Dependent Claim
63 words
An L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptide of the formula ##STR4## wherein A is an alkylene radical having up to 5 carbon atoms which can be substituted by a hydroxyl group or by a phenyl radical which optionally carries at least one hydroxyl group, and R is a hydrogen atom or a lower alkyl radical or a glycyl or alanyl radical, or a pharmacologically compatible salt thereof.
Claim 3
Dependent Claim
26 words
A peptide or salt thereof according to claim 1, wherein A is an alkylene radical having up to 5 carbon atoms substituted by a hydroxyl group.
Claim 4
Dependent Claim
33 words
A peptide or salt thereof according to claim 1, wherein A is an alkylene radical having up to 5 carbon atoms and substituted by a phenyl radical which can carry a hydroxyl group.
Claim 5
Dependent Claim
25 words
A peptide or salt thereof according to claim 1, wherein R is a hydrogen atom or an alkyl radical having up to 3 carbon atoms.
Claim 6
Dependent Claim
15 words
A peptide or salt thereof according to claim 1, wherein R is a glycyl radical.
Claim 7
Dependent Claim
15 words
A peptide or salt thereof according to claim 1, wherein R is an alanyl radical.
Claim 8
Dependent Claim
14 words
A peptide or salt thereof according to claim 1, wherein said peptide is glycyl-L-3-(3,4-dihydroxyphenyl)-2-methylalanine.
Claim 9
Dependent Claim
14 words
A peptide or salt thereof according to claim 1, wherein said peptide is L-alanyl-L-3-(3,4-dihydroxyphenyl)-2-methylalanine.
Claim 10
Dependent Claim
14 words
A peptide or salt thereof according to claim 1, wherein said peptide is L-seryl-L-3-(3,4-dihydroxyphenyl)-2-methylalanine.
Claim 11
Dependent Claim
14 words
A peptide or salt thereof according to claim 1, wherein said peptide is L-alanyl-L-alanyl-L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine.
Claim 12
Dependent Claim
33 words
A blood pressure-lowering composition, comprising a blood pressure-lowering effective amount of at least one peptide or salt thereof according to claim 1, in admixture with a solid or liquid pharmaceutical diluent or carrier.
Claim 13
Dependent Claim
31 words
The method of lowering the blood pressure of a subject which comprises administering to said subject a blood pressure-lowering effective amount of a peptide or salt thereof according to claim 1.
Claim 14
Dependent Claim
15 words
The method according to claim 12, wherein said peptide is glycyl-L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine, L-alanyl-L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine, L-seryl-L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine or L-alanyl-L-alanyl-L-3-(3,4-dihydroxyphenyl)-2-methylalanine.
References Cited (Backward Citations)
US3803120A
Cited
US3891696A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |