US4420491A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypocholesteremic fermentation products and process of preparation
Assignee: Merck and Co Inc
•
Filing: 1981-05-28
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Granted: 1983-12-13
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Expires: 2001-05-28
Abstract
Abstract Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: <IMAGE> I <IMAGE> II Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
Inventors
- 👤 George Albers-Schonberg
- 👤 Henry Joshua
- 👤 Maria B. Lopez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:08
CPC Classifications
C; C12; C12P; C12P17/00; C12P17/02; C12P17/06; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C12P7/00; C12P7/62
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
31 words
The compound: ##STR6## in substantially pure form or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 2
Dependent Claim
31 words
The compound: ##STR6## in substantially pure form or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 3
Dependent Claim
23 words
The pharmaceutically acceptable salts of the compound of claim 1, wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
Claim 4
Dependent Claim
9 words
The ammonium salt of Compound II of claim 1.
Claim 5
Dependent Claim
9 words
The ethylenediamine salt of Compound II of claim 1.
Claim 6
Dependent Claim
15 words
The lower alkyl esters and substituted lower alkyl esters of the compounds of claim 1.
Claim 7
Dependent Claim
9 words
The ethyl ester of Compound II of claim 1.
Claim 8
Dependent Claim
45 words
An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of the compound: ##STR7## in substantially pure form or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 9
Dependent Claim
45 words
An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of the compound: ##STR7## in substantially pure form or a pharmaceutically acceptable salt or a lower alkyl ester or a substituted lower alkyl ester wherein the substituent is phenyl, dimethylamino, or acetylamino.
Claim 10
Dependent Claim
26 words
The composition of claim 7 wherein the compound is a pharmaceuticaly acceptable salt wherein the cation is derived from ammonia, ethylenediamine, N-methylglucamine, lysine, arginine or ornithine.
Claim 11
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ammonium salt of Compound II.
Claim 12
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ethylenediamine salt of Compound II.
Claim 13
Dependent Claim
18 words
The composition of claim 7 wherein the compound is a lower alkyl ester or substituted lower alkyl ester.
Claim 14
Dependent Claim
15 words
The composition of claim 7 wherein the compound is the ethyl ester of Compound II.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-12 | 1987-06-13 | 1987-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-12 | 1991-06-13 | 1991-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-12 | 1995-06-13 | 1995-12-13 | $7700.00 | Window Closed / Lapsed |