Basic amino or ammonium antimicrobial agent-polyethylene glycol ester surfactant-betaine and/or amine oxide surfactant compositions and method of use therof

Claim 1

An antimicrobial skin cleansing composition consisting essentially of (A) an antimicrobially effective amount of one or more antimicrobial agents selected from the group consisting of (a) a compound having the structural formula ##STR14## wherein R taken alone is phenyl substituted by alkyl, alkoxy, nitro or halo, p-(2,2-dichlorocyclopropyl)phenyl, alkyl having from 6 to 16 carbon atoms, cycloalkyl or polycyclic alkyl having more than 6 carbon atoms or lower-alkyl-cycloalkyl or cycloalkyl-lower-alkyl having from 1 to 4 carbons in lower alkyl; R' taken alone is hydrogen; R and R' taken together are 3-azabicyclo(3,2,2)nonyl; and n is an integer from 3 to 9; or a pharmaceutically acceptable salt thereof; (b) a compound having the structural formula ##STR15## wherein R 1 is long-chain alkyl or aralkyl; R 2 is short-chain alkyl, long-chain alkyl or aralkyl, benzyl or part of an aromatic system or non-aromatic system; R 3 and R 4 are short-chain alkyl or part of an aromatic ring system or non-aromatic ring system; Z is a carbon-hydrogen chain; and X is a pharmaceutically acceptable anion; and (c) a compound having the structural formula ##STR16## wherein R is an alkyl group containing from 6 to 18 carbon atoms, a cycloalkyl group containing from 5 to 7 carbon atoms, benzyl, benzyl substituted by one or two substituents selected from the group consisting of halogen, hydroxy, lower-alkyl, lower-alkoxy, nitro, cyano and trifluoromethyl or phenyl substituted by methylenedioxy or one or two substituents selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, nitro, cyano and trifluoromethyl; Y is an alkylene group containing from 4 to 18 carbon atoms and separating the two 4-(R-NH)-1-pyridinyl groups by from 4 to 18 carbon atoms; A is a pharmaceutically acceptable anion; m is 1 or 3; n is 1 or 2; x is 1, 2 or 3; and (m)(2)=(n)(x); (B) from about 0.75% to about 30% by weight of one or more polyethylene glycol ester surfactants having the structural formulas ##STR17## wherein R is alkyl or alkenyl having from about 8 to about 20 carbon atoms or lanolin and n is an integer from about 8 to about 200; (C) from about 0.5% to about 30% by weight of one or more surfactants selected from the group consisting of (a) betaines having the structural formulas ##STR18## wherein R 1 is alkyl or alkenyl having from about 8 to about 18 carbon atoms; R 2 is methyl, ethyl or 2-hydroxyethyl; R 3 is 2-hydroxyethyl or CH 2 COO - ; R 4 is CH 2 COO - or CH 2 CH 2 -O-CH 2 COO - ; an n is 2 or 3; and (b) amine oxides having the structural formula ##STR19## wherein R 1 taken alone is methyl, ethyl or 2-hydroxyethyl; R 2 taken alone is methyl, ethyl or 2-hydroxyethyl; R 1 and R 2 taken together are morpholino; R 3 is alkyl having from about 8 to about 18 carbon atoms or R 4 CONH(CH 2 ) 3 wherein R 4 is alkyl having from about 8 to about 18 carbon atoms; and wherein 2-hydroxyethyl can be condensed with from 1 to about 200 units of ethylene oxide; and (D) water, aqueous ethyl alcohol, aqueous isopropyl alcohol or an aqueous ethyl alcohol-isopropyl alcohol mixture.