US4022834A
Expired / Lapsed
US
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Antibacterially active hexamethylene-bis-biguanides
Assignee: Farmaceutisk Industri AS
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Filing: 1975-05-01
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Granted: 1977-05-10
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Expires: 1995-05-01
Abstract
Abstract There are disclosed new hexamethylene-bis-biguanides having antibacterial activity, and two processes for the preparation thereof. The new compounds have the general formula ##STR1## wherein R represents H, and R' represents an hexyl or pentyl group being substituted with one or two methyl groups, or represents a cycloalkyl group having more than 6 carbon atoms, a lower-alkyl-cycloalkyl group or a cycloalkyl-lower-alkyl group, or R and R' together with the adjacent nitrogen atom represent an azabicyclo(3,2,2)-nonane double ring.
Inventors
- 👤 Helge Guttorm Gundersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 07:48
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/215; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/43; A61Q; A61Q11/00; C07C; C07C279/00; C07C279/20; C07C279/24; C07C279/26; C07C279/265
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
45 words
A compound of the formula ##STR6## wherein R represents H and R' is selected from the group consisting of 1-adamantyl, 2-norbonyl and cyclohexylmethyl or wherein R and R' together with the adjacent nitrogen atom form a 3-azabicyclo(3,2,2)-nonane double ring and pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
45 words
A compound of the formula ##STR6## wherein R represents H and R' is selected from the group consisting of 1-adamantyl, 2-norbonyl and cyclohexylmethyl or wherein R and R' together with the adjacent nitrogen atom form a 3-azabicyclo(3,2,2)-nonane double ring and pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
9 words
Compound according to claim 1, wherein R'=1-adamantyl and R=H.
Claim 4
Dependent Claim
9 words
Compound according to claim 1, wherein R'=2-norbornyl and R=H.
Claim 5
Dependent Claim
9 words
Compound according to claim 1, wherein R'=cyclohexylmethyl and R=H.
Claim 6
Dependent Claim
21 words
Compound according to claim 1, in which R' and R together with the adjacent nitrogen atom form a 3-azabicyclo(3,2,2)-nonane double ring.
References Cited (Backward Citations)
US3468898A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |