Patent US2268939A successfully refreshed from Google Patents.
Patent US4414147A successfully refreshed from Google Patents.
US4414147A
Expired / Lapsed
US
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Methods of decreasing the hydrophobicity of fibroblast and other interferons
Assignee: Massachusetts Institute of Technology
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Filing: 1981-04-17
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Granted: 1983-11-08
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Expires: 2001-04-17
Abstract
Abstract A method for improving the stability and usefulness of interferon, including human fibroblast interferon, is disclosed. In this method, interferon is bonded to a non-hydrophobic substance to create a molecular complex that is less hydrophobic than untreated interferon.
Inventors
- 👤 Alexander M. Klibanov
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:01
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/215; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
31 words
A method of reducing the hydrophobicity of interferon, comprising contacting said interferon with an anhydride of a dicarboxylic acid under conditions that allow said interferon to become bonded to said anhydride.
Claim 2
Independent Claim
31 words
A method of reducing the hydrophobicity of interferon, comprising contacting said interferon with an anhydride of a dicarboxylic acid under conditions that allow said interferon to become bonded to said anhydride.
Claim 3
Dependent Claim
25 words
A method of claim 1 wherein said anhydride is selected from the following group: succinic anhydride, maleic anhydride, poly(ethylene maleic anhydride), and poly(ethylene succinic anhydride).
Claim 4
Dependent Claim
19 words
A composition of matter comprising a molecule of interferon that is bonded to an anhydride of a dicarboxylic acid.
Claim 5
Dependent Claim
19 words
A composition of matter comprising a molecule of interferon that is bonded to an anhydride of a dicarboxylic acid.
References Cited (Backward Citations)
US4061538A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-07 | 1987-05-09 | 1987-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-07 | 1991-05-09 | 1991-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-07 | 1995-05-09 | 1995-11-08 | $7700.00 | Window Closed / Lapsed |