US4410514A
Expired / Lapsed
US
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GnRH Agonists
Assignee: Salk Institute for Biological Studies
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Filing: 1982-12-06
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Granted: 1983-10-18
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Expires: 2002-12-06
Abstract
Abstract Peptides for promoting the spawning of fish having the formula: pGlu--His--Trp--Ser--Tyr--R.sub.6 --Trp--Leu--Pro--R.sub.10 --NHR or a nontoxic salt thereof, wherein R 6 is a D-isomer of an α-amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R 10 is Gly or des-R 10 and R is H or C n Y 2n CY 3 , with Y being H or F and n being 0, 1, 2 or 3, provided that when R 10 is des-R 10 , n is not 0. The D-isomer α-amino acids may contain known substitutions.
Inventors
- 👤 Wylie W. Vale, Jr.
- 👤 Jean E. F. Rivier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:54
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
102 words
A peptide having the formula pGlu--His--Trp--Ser--Tyr--R.sub.6 --Trp--Leu--Pro--R.sub.10 --NHR or a nontoxic salt thereof, wherein R 6 is a D-isomer of an α-amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R 10 is Gly or des-R 10 and R is H or C n Y 2n CY 3 , with Y being H or F and n being 0, 1, 2 or 3, provided that when R 10 is des-R 10 , n is not 0.
Claim 2
Dependent Claim
102 words
A peptide having the formula pGlu--His--Trp--Ser--Tyr--R.sub.6 --Trp--Leu--Pro--R.sub.10 --NHR or a nontoxic salt thereof, wherein R 6 is a D-isomer of an α-amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R 10 is Gly or des-R 10 and R is H or C n Y 2n CY 3 , with Y being H or F and n being 0, 1, 2 or 3, provided that when R 10 is des-R 10 , n is not 0.
Claim 3
Dependent Claim
12 words
A peptide in accordance with claim 1 wherein R 6 is D-Ala.
Claim 4
Dependent Claim
21 words
A peptide in accordance with claim 1 wherein R 10 is des-R 10 , Y is H and n is 1.
Claim 5
Dependent Claim
21 words
A peptide in accordance with claim 2 wherein R 10 is des-R 10 , Y is H and n is 1.
Claim 6
Independent Claim
111 words
A method of promoting the spawning of fish by administering an effective amount of pGlu--His--Trp--Ser--Tyr--R.sub.6 --Trp--Leu--Pro--R.sub.10 --NHR or a nontoxic salt thereof wherein R 6 is a D-isomer of an α-amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R 10 is Gly or des-R 10 and R is H or C n Y 2n CY 3 , with Y being H or F and n being 0, 1, 2 or 3, provided that when R 10 is des-R 10 , n is not 0.
Claim 7
Independent Claim
111 words
A method of promoting the spawning of fish by administering an effective amount of pGlu--His--Trp--Ser--Tyr--R.sub.6 --Trp--Leu--Pro--R.sub.10 --NHR or a nontoxic salt thereof wherein R 6 is a D-isomer of an α-amino acid selected from the group consisting of Trp, Ala, Phe, Lys, Pro, Met, Leu, Glu, Asn, Arg, Tyr, Cys, His, Chg, Nva, Orn, Thr, Abu, Phg, Ile, Glu, Asp, Nle and Val and wherein R 10 is Gly or des-R 10 and R is H or C n Y 2n CY 3 , with Y being H or F and n being 0, 1, 2 or 3, provided that when R 10 is des-R 10 , n is not 0.
Claim 8
Dependent Claim
13 words
A method in accordance with claim 5 wherein said administering is by injection.
Claim 9
Dependent Claim
27 words
A method in accordance with claim 6 wherein a dosage of not greater than about 100 μg is administered for each 100 g. of fish body weight.
Claim 10
Dependent Claim
20 words
A method in accordance with claim 5 wherein said administering is by dissolving in water wherein the fish are swimming.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1986-10-17 | 1987-04-18 | 1987-10-18 | $2000.00 | Window Closed / Lapsed |
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