US4003884A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptides having LH-RH/FSH-RH activity
Assignee: Hoechst AG
•
Filing: 1975-05-16
•
Granted: 1977-01-18
•
Expires: 1995-05-16
Abstract
Abstract Peptides having LH-RH/FSH-RH activity useful for treatment of male and female sterility.
Inventors
- 👤 Wolfgang Konig
- 👤 Rolf Geiger
- 👤 Jurgen K. Sandow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:54
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
93 words
A peptide of the general formula ##STR5##wherein X represents Ser(Bu t ), Cys(Bu t ), Asp(OBu t ), Glu (OBu t ), Orn(Boc) or Lys(Boc) and Y is glycinamide or a NH-alkyl group wherein the alkyl radical contains 1 to 3 carbon atoms and may be substituted by OH groups or halogen atoms, or Y is the NH-cyclopropyl radical and wherein Trp may be substituted by pentamethylphenyl alanine, Ser by Ala or Thr, Tyr by Phe, Gly by D-amino acids corresponding to the naturally occuring L-amino acids, Arg by Orn, Lys or homoarginine.
Claim 2
Dependent Claim
93 words
A peptide of the general formula ##STR5##wherein X represents Ser(Bu t ), Cys(Bu t ), Asp(OBu t ), Glu (OBu t ), Orn(Boc) or Lys(Boc) and Y is glycinamide or a NH-alkyl group wherein the alkyl radical contains 1 to 3 carbon atoms and may be substituted by OH groups or halogen atoms, or Y is the NH-cyclopropyl radical and wherein Trp may be substituted by pentamethylphenyl alanine, Ser by Ala or Thr, Tyr by Phe, Gly by D-amino acids corresponding to the naturally occuring L-amino acids, Arg by Orn, Lys or homoarginine.
Claim 3
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Ser(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 4
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Ser(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 5
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Cys(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 6
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Cys(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 7
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Glu(OBu t )-Arg-Pro-NHC 2 H 5 .
Claim 8
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-Gly-Glu(OBu t )-Arg-Pro-NHC 2 H 5 .
Claim 9
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-D-Ala-Ser(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 10
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-D-Ala-Ser(Bu t )-Arg-Pro-NHC 2 H 5 .
Claim 11
Dependent Claim
3 words
Glu-His-Trp-Ser-Tyr-D-Leu-Ser(Bu t )-Arg-Pro-cyclopropylamide.
Claim 12
Dependent Claim
3 words
Glu-His-Trp-Ser-Tyr-D-Leu-Ser(Bu t )-Arg-Pro-cyclopropylamide.
Claim 13
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-D-Leu-Cys(Bu t )-Arg-Pro-NH-C 2 H 5 .
Claim 14
Dependent Claim
7 words
Glu-His-Trp-Ser-Tyr-D-Leu-Cys(Bu t )-Arg-Pro-NH-C 2 H 5 .
References Cited (Backward Citations)
US3856769A
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US3780014A
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US3790554A
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US3835108A
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US3803117A
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US3888838A
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US3880825A
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US3826796A
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US3914412A
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US3892723A
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US3901872A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-18 | 1980-07-19 | 1981-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-18 | 1984-07-19 | 1985-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-18 | 1988-07-19 | 1989-01-18 | $7700.00 | Window Closed / Lapsed |