Patent US4407804A successfully refreshed from Google Patents.
US4407804A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesic mixture of nalbuphine and indomethacin
Assignee: Bristol Myers Squibb Pharma Co
•
Filing: 1982-06-30
•
Granted: 1983-10-04
•
Expires: 2002-06-30
Abstract
Abstract Pharmaceutical compositions of nalbuphine and indomethacin have been found to exhibit unexpectedly enhanced analgesic activity by applying an analysis model which considers data characterizing the analgesic effect of both the pure components as well as the fixed dose ratio combinations. This synergism enables the use of lower doses of either or both drugs with a concomitant reduction in risk of possible side effects.
Inventors
- 👤 William K. Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
38 words
A pharmaceutical composition comprising a combination of (a) nalbuphine, or a pharmaceutically acceptable salt thereof, and (b) indomethacin, or a pharmaceutically suitable salt thereof, in which the weight ratio of (a):(b) is from about 1:0.01 to about 1:20.
Claim 2
Dependent Claim
38 words
A pharmaceutical composition comprising a combination of (a) nalbuphine, or a pharmaceutically acceptable salt thereof, and (b) indomethacin, or a pharmaceutically suitable salt thereof, in which the weight ratio of (a):(b) is from about 1:0.01 to about 1:20.
Claim 3
Dependent Claim
18 words
The composition of claim 1 wherein the weight ratio of (a):(b) is from about 1:0.01 to about 1:0.366.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein the nalbuphine is present as the hydrochloride salt.
Claim 5
Dependent Claim
14 words
The composition of claim 1 wherein the indomethacin is present as the sodium salt.
Claim 6
Dependent Claim
13 words
The composition of claim 1 which contains in addition a suitable pharmaceutical carrier.
Claim 7
Dependent Claim
13 words
The composition of claim 2 which contains in addition a suitable pharmaceutical carrier.
Claim 8
Dependent Claim
13 words
The composition of claim 3 which contains in addition a suitable pharmaceutical carrier.
Claim 9
Dependent Claim
13 words
The composition of claim 4 which contains in addition a suitable pharmaceutical carrier.
Claim 10
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 1.
Claim 11
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 2.
Claim 12
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 3.
Claim 13
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 4.
Claim 14
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 5.
Claim 15
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 6.
Claim 16
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 7.
Claim 17
Dependent Claim
27 words
A method of alleviating pain in a mammal which comprises administering to said mammal affected with pain an effective analgesic amount of the composition of claim 8.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-03 | 1987-04-04 | 1987-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-03 | 1991-04-04 | 1991-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-03 | 1995-04-04 | 1995-10-04 | $7700.00 | Window Closed / Lapsed |