US4405600A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods and materials for prevention of carious degradation of teeth
Assignee: University Patents Inc
•
Filing: 1980-04-11
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Granted: 1983-09-20
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Expires: 2000-04-11
Abstract
Abstract Cariogenic substances such as foodstuffs are treated to incorporate a soluble source of calcium or phosphate ions to provide a product of calcium and phosphate ion concentrations in fluids of salivary retention areas preclusive of carious dissolution of dental enamel. In non-aqueous foodstuffs, the calcium or phosphate ion source should be at least as rapidly soluble as cariogenic, e.g., carbohydrate, components therein. Also provided are mouth rinse solutions comprising a soluble source of calcium or phosphate ions and an osmotically active agent effective in delivering such ions to fluids trapped in salivary retention areas.
Inventors
- 👤 Frank C. Besic
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:26
CPC Classifications
A; A23; A23G; A23G3/00; A23G3/34; A23G3/36; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/24; A61Q; A61Q11/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
56 words
A method for diminishing the cariogenicity of sucrose, said method consisting of admixing sucrose with a soluble source of calcium ions or a soluble source of phosphate ions in a quantitative weight ratio of about one part ion source to forty parts sucrose, said ion source being at least as rapidly soluble in water as sucrose.
Claim 2
Independent Claim
56 words
A method for diminishing the cariogenicity of sucrose, said method consisting of admixing sucrose with a soluble source of calcium ions or a soluble source of phosphate ions in a quantitative weight ratio of about one part ion source to forty parts sucrose, said ion source being at least as rapidly soluble in water as sucrose.
Claim 3
Dependent Claim
26 words
The method of claim 1 wherein said admixing step comprises dissolving the sucrose and soluble source of ions in water and then evaporating the water solvent.
Claim 4
Dependent Claim
38 words
The method of claim 1 wherein the ion source is a calcium ion source and wherein the quantity of calcium ion sources employed is sufficient to provide at least about 3.25 mg calcium ion per gram of sucrose.
Claim 5
Dependent Claim
13 words
The method of claim 3 wherein said calcium ion source is calcium propionate.
Claim 6
Dependent Claim
37 words
The method of claim 1 wherein the ion source is a phosphate ion source and wherein the quantity of phosphate ion source provided is sufficient to provide at least about 1.08 mg phosphate per gram of sucrose.
Claim 7
Dependent Claim
14 words
The method of claim 5 wherein said phosphate ion source is monohydric sodium orthophosphate.
Claim 8
Independent Claim
122 words
A method for preventing carious degradation of tooth surfaces in salivary retention areas of the mouth, said method comprising administering to the mouth a soluble source of calcium ions or a soluble source of phosphate ions in combination with an effective amount of an osmotically active agent, whereby said osmotically active agent promotes transfer of calcium ions or phosphate ions from the mouth into saliva in said salivary retention areas in quantities such that, taking into account calcium and phosphate ions already present in the saliva, the ratio of calcium ions to phosphate ions therein is from about 0.0666 to about 4.223 and the product of the concentration of calcium ions to phosphate ions therein is from about 0.5 to about 20.
Claim 9
Independent Claim
122 words
A method for preventing carious degradation of tooth surfaces in salivary retention areas of the mouth, said method comprising administering to the mouth a soluble source of calcium ions or a soluble source of phosphate ions in combination with an effective amount of an osmotically active agent, whereby said osmotically active agent promotes transfer of calcium ions or phosphate ions from the mouth into saliva in said salivary retention areas in quantities such that, taking into account calcium and phosphate ions already present in the saliva, the ratio of calcium ions to phosphate ions therein is from about 0.0666 to about 4.223 and the product of the concentration of calcium ions to phosphate ions therein is from about 0.5 to about 20.
Claim 10
Dependent Claim
49 words
Sucrose in crystalline form having a soluble source of calcium ions or a soluble source of phosphate ions uniformly distributed therethrough in a quantitative weight ratio of about one part ion source to forty parts sucrose, said ion source being at least as rapidly soluble in water as sucrose.
Claim 11
Dependent Claim
49 words
Sucrose in crystalline form having a soluble source of calcium ions or a soluble source of phosphate ions uniformly distributed therethrough in a quantitative weight ratio of about one part ion source to forty parts sucrose, said ion source being at least as rapidly soluble in water as sucrose.
Claim 12
Dependent Claim
46 words
Sucrose in crystalline form according to claim 8 wherein the uniform distribution of soluble source of calcium ions or phosphate ions is the result of the dissolution of the sucrose and the soluble source of ions in water and the subsequent evaporation of the water solvent.
Claim 13
Dependent Claim
16 words
An aqueous solution formed by dissolving sucrose in crystalline form according to claim 8 in water.
Claim 14
Dependent Claim
39 words
Sucrose in crystalline form as in claim 8 wherein the ion source is a calcium ion source and wherein the calcium ion source employed is sufficient to provide at least about 3.25 mg calcium ion per gram of sucrose.
Claim 15
Dependent Claim
16 words
Sucrose in crystalline form as in claim 11 wherein said calcium ion source is calcium propionate.
Claim 16
Dependent Claim
41 words
Sucrose in crystalline form as in claim 8 wherein the ion source is a phosphate ion source and wherein the quantity of phosphate ion source employed is sufficient to provide at least about 1.08 mg of phosphate per gram of sucrose.
Claim 17
Dependent Claim
16 words
Sucrose in crystalline form as in claim 13 wherein said phosphate ion source is sodium orthophosphate.
Claim 18
Dependent Claim
71 words
A foodstuff containing sucrose in crystalline form having a soluble source of calcium ions distributed therethrough as a result of dissolution of the sucrose and the soluble source of calcium ions in water and the subsequent evaporation of the water solvent, said calcium ion source being at least as rapidly soluble in water as sucrose and there being present at least about 3.25 mg of calcium ions per gram of sucrose.
Claim 19
Dependent Claim
71 words
A foodstuff containing sucrose in crystalline form having a soluble source of calcium ions distributed therethrough as a result of dissolution of the sucrose and the soluble source of calcium ions in water and the subsequent evaporation of the water solvent, said calcium ion source being at least as rapidly soluble in water as sucrose and there being present at least about 3.25 mg of calcium ions per gram of sucrose.
Claim 20
Dependent Claim
120 words
A cariostatic mouth rinse, the cariostatically active ingredients of which consist of an aqueous solution of a source of calcium ions and an osmotically active agent, the quantities of calcium ions and osmotically active agents in said mouth rinse being such that upon administration to the mouth the osmotically active agent promotes transfer of calcium ions from the mouth into saliva in salivary retention areas in the mouth in quantities such that, taking into account calcium and phosphate ions already present in the saliva, the ratio of calcium ions to phosphate ions therein is from about 0.0666 to about 4.223 and the product of the concentration of calcium ions to phosphate ions therein is from about 0.5 to about 20.
Claim 21
Dependent Claim
120 words
A cariostatic mouth rinse, the cariostatically active ingredients of which consist of an aqueous solution of a source of calcium ions and an osmotically active agent, the quantities of calcium ions and osmotically active agents in said mouth rinse being such that upon administration to the mouth the osmotically active agent promotes transfer of calcium ions from the mouth into saliva in salivary retention areas in the mouth in quantities such that, taking into account calcium and phosphate ions already present in the saliva, the ratio of calcium ions to phosphate ions therein is from about 0.0666 to about 4.223 and the product of the concentration of calcium ions to phosphate ions therein is from about 0.5 to about 20.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |