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US4401646A
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Method and apparatus for purifying materials radiolabeled with technetium-99m
Assignee: University Patents Inc
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Filing: 1981-05-08
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Granted: 1983-08-30
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Expires: 2001-05-08
Abstract
Abstract Compositions labeled with technetium-99m are purified by passage through a filtration column which contains a reducing agent, colloidal stannous phthalate, antioxidant and a particulate solid substrate capable of binding reduced technetium and of retaining insoluble technetium such as reduced hydrolyzed technetium.
Inventors
- 👤 Buck A. Rhodes
- 👤 David Torvestad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:37
CPC Classifications
B; B01; B01D; B01D15/00; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K51/048; A61K2123/00; Y; Y10; Y10S; Y10S422/00; Y10S422/903
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
64 words
The process of purifying a composition labeled with technetium- 99m and containing unbound reduced technetium impurity and/or pertechnetate impurity which comprises contacting said labeled composition with a solid particulate substrate containing stannous phthalate precipitated from a saturated solution and a secondary antioxidant, said substrate being capable of binding a technetate ion and capable of retaining unbound reduced technetium impurity and recovering purified labeled composition.
Claim 2
Dependent Claim
64 words
The process of purifying a composition labeled with technetium- 99m and containing unbound reduced technetium impurity and/or pertechnetate impurity which comprises contacting said labeled composition with a solid particulate substrate containing stannous phthalate precipitated from a saturated solution and a secondary antioxidant, said substrate being capable of binding a technetate ion and capable of retaining unbound reduced technetium impurity and recovering purified labeled composition.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein said secondary antioxidant is gentisic acid.
Claim 4
Dependent Claim
12 words
The process of claim 1 wherein said secondary antioxidant is ascorbic acid.
Claim 5
Dependent Claim
12 words
The process of claim 1 wherein said particulate substrate is cross-linked dextran.
Claim 6
Dependent Claim
12 words
The process of claim 1 wherein said composition is 99m Tc-methylene diphosphonate.
Claim 7
Dependent Claim
12 words
The process of claim 1 wherein said composition is 99m -Tc-diethylenediaminepentaacetic acid.
Claim 8
Dependent Claim
48 words
Apparatus for purifying a composition labeled with technetium-99m which comprises a closed container having an inert non-oxidizing atmosphere and containing a solid particulate substrate capable of binding technetate ion and capable of retaining unbound reduced technetium impurity, stannous phthalate precipitated from a saturated solution and a secondary antioxidant.
Claim 9
Dependent Claim
48 words
Apparatus for purifying a composition labeled with technetium-99m which comprises a closed container having an inert non-oxidizing atmosphere and containing a solid particulate substrate capable of binding technetate ion and capable of retaining unbound reduced technetium impurity, stannous phthalate precipitated from a saturated solution and a secondary antioxidant.
Claim 10
Dependent Claim
12 words
The apparatus of claim 7 wherein said secondary antioxidant is gentistic acid.
Claim 11
Dependent Claim
12 words
The apparatus of claim 7 wherein said secondary antioxidant is ascorbic acid.
Claim 12
Independent Claim
18 words
The apparatus of any one of claims 7, 8 or 9 wherein said particulate substrate is cross-linked dextran.
Claim 13
Dependent Claim
11 words
The process of claim 1 wherein said composition is 99m Tc-protein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-29 | 1987-02-28 | 1987-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-29 | 1991-02-28 | 1991-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-29 | 1995-02-28 | 1995-08-30 | $7700.00 | Window Closed / Lapsed |