US4187285A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microaggregated albumin
Assignee: Bracco International BV
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Filing: 1977-12-16
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Granted: 1980-02-05
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Expires: 1997-12-16
Abstract
Abstract A composition suitable for labeling with technetium-99 m and subsequent use as an agent for the imaging of the reticuloendothelial system comprising microaggregated particles of denatured albumin having stannous ions bound thereto and being substantially free of buffer, and a process for preparing such a composition are disclosed herein.
Inventors
- 👤 Marion Meeks
- 👤 R. K. Narra
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:00
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/1241; A61K51/1255; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
31 words
A composition comprising microaggregated denatured albumin having stannous ions bound thereto, having a particle size in the range of about 0.1 to 3 microns, said composition being substantially free of buffer.
Claim 2
Dependent Claim
31 words
A composition comprising microaggregated denatured albumin having stannous ions bound thereto, having a particle size in the range of about 0.1 to 3 microns, said composition being substantially free of buffer.
Claim 3
Dependent Claim
40 words
A process for preparing aggregates of denatured albumin having stannous ions bound thereto which comprises mixing together normal human serum albumin, a dilute acid solution, an aqueous solution of a stannous salt and a buffer and heating the resulting mixture.
Claim 4
Dependent Claim
40 words
A process for preparing aggregates of denatured albumin having stannous ions bound thereto which comprises mixing together normal human serum albumin, a dilute acid solution, an aqueous solution of a stannous salt and a buffer and heating the resulting mixture.
Claim 5
Dependent Claim
24 words
A process in accordance with claim 2 wherein the weight ratio of normal human serum albumin to stannous ion is about 5:1 to 20:1.
Claim 6
Dependent Claim
22 words
A process in accordance with claim 2 wherein the weight ratio of normal human serum albumin to stannous ion is about 7.7:1.
Claim 7
Dependent Claim
22 words
A process in accordance with claim 2 wherein the mixture is heated to a temperature of about 75° C. to 85° C.
Claim 8
Dependent Claim
39 words
A process in accordance with claim 2 which further comprises washing the aggregates to remove substantially all of the buffer and adjusting to size of the aggregates to within the range of about 0.1 to 3 microns by ultrasonication.
References Cited (Backward Citations)
US3872226A
Cited
US4094965A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-04 | 1983-08-06 | 1984-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-04 | 1987-08-06 | 1988-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-04 | 1991-08-06 | 1992-02-05 | $7700.00 | Window Closed / Lapsed |