US4395559A
Expired / Lapsed
US
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2,3-Indoledione derivatives
Assignee: Hoffmann La Roche Inc
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Filing: 1980-12-01
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Granted: 1983-07-26
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Expires: 2000-12-01
Abstract
Abstract 2,3-Indoledione derivatives of the formula <IMAGE> I wherein R is isopropyl or tert.butyl, R1 is hydrogen or lower alkyl and R2 is lower alkyl or lower aralkyl, and their pharmaceutically acceptable acid addition salts, prepared from a compound of the formula <IMAGE> II wherein R3 is hydroxy and R4 is chlorine or bromine or R3 and R4, taken together, are oxygen, and R1 and R2 are as previously set forth, are described. The compounds of formula I and their pharmaceutically acceptable addition salts are useful as beta -adrenergic blocking agents and antihypertensive agents.
Inventors
- 👤 Graham A. Fothergill
- 👤 John M. Osbond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:25
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/32; C07D209/38; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
36 words
A compound of the formula ##STR10## wherein R is isopropyl or tert.butyl, R 1 is hydrogen or lower alkyl, and R 2 is lower alkly, benzyl or β-phenethyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
36 words
A compound of the formula ##STR10## wherein R is isopropyl or tert.butyl, R 1 is hydrogen or lower alkyl, and R 2 is lower alkly, benzyl or β-phenethyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
26 words
A compound in accordance with claim 1, wherein R 1 is hydrogen, and R 2 is lower alkyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
8 words
A compound in accordance with claim 1, 7-(3-tert.butylamino-2-hydroxypropoxy)-1-methyl-2,3-indoledione.
Claim 5
Dependent Claim
8 words
A compound in accordance with claim 1, 7-(3-tert.butylamino-2-hydroxypropoxy)-1,4-dimethyl-2,3-indoledione.
Claim 6
Dependent Claim
8 words
A compound in accordance with claim 1, 7-(2-hydroxy-3-isopropylaminopropoxy)-1,4-dimethyl-2,3-indoledione.
Claim 7
Dependent Claim
8 words
A compound in accordance with claim 1, 1-benzyl-7-(3-tert.butylamino-2-hydroxypropoxy)-4-methyl-2,3-indoledione.
Claim 8
Dependent Claim
44 words
A compound of the formula ##STR11## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, benzyl or β-phenethyl, R 3 is hydroxy, and R 4 is chlorine or bromine, or R 3 and R 4 , taken together, are oxygen.
Claim 9
Dependent Claim
44 words
A compound of the formula ##STR11## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, benzyl or β-phenethyl, R 3 is hydroxy, and R 4 is chlorine or bromine, or R 3 and R 4 , taken together, are oxygen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-25 | 1987-01-24 | 1987-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-25 | 1991-01-24 | 1991-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-25 | 1995-01-24 | 1995-07-26 | $7700.00 | Window Closed / Lapsed |