Propanolamine derivatives

Abstract

Abstract Laevorotatory compounds of the general formula ArOCH2CH(OH)CH2NHR (wherein R stands for an alkyl radical optionally substituted by an alkoxy or hydroxy radical, a cycloalkyl or alkenyl radical, or for an aralkyl radical optionally substituted by an alkyl or alkoxy radical, and Ar stands for a naphthyl radical optionally substituted by one or more halogen atoms or alkyl radicals, or for the phenyl radical substituted by an alkylene radical or by one or more substituents selected from halogen atoms, alkyl, alkoxy, aryloxy and hydroxy radicals, or Ar stands for a substituted phenyl radical of the formula <FORM:1069343/C2/1> wherein the ring A is a 5-, 6-, 7- or 8-membered heterocyclic ring containing one or more oxygen and/or nitrogen atoms as heteroatom(s)) and their acid addition salts are prepared by resolving the corresponding racemic compound by means of an optically active acid, optionally followed by conversion to the free base or a different salt. The preparation of a number of the racemic starting materials is described. The compounds of the invention are of value in the treatment or prophylaxis of heart diseases, and may be administered in the form of pharmaceutical preparations containing them together with a diluent or carrier.

Inventors

• 👤 Ralph Howe

Bibliographic Details