US4137331A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
Assignee: Sandoz AG
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Filing: 1976-12-16
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Granted: 1979-01-30
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Expires: 1996-12-16
Abstract
Abstract This invention provides new compounds of formula I, <IMAGE> I wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, and R is the group A, B, C or D, <IMAGE> A <IMAGE> B <IMAGE> C <IMAGE> D wherein N IS THE NUMBER 2 OR 3, N' IS THE NUMBER 1, 2, 3 OR 4, AND X-X' is ethylene or vinylene, WHEREIN IN GROUP D each of the two C atoms adjacent to the N atom are identically substituted by hydrogen or by one or two alkyl groups of 1 to 4 carbon atoms useful as antiarrhythmic agents.
Inventors
- 👤 Richard Berthold
- 👤 Franz Troxler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:27
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/73; C07D203/00; C07D203/04; C07D203/06; C07D203/08; C07D203/10; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/42; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D451/00; C07D451/02; C07D451/14
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
57 words
A compound of the formula ##STR8## wherein Het is 2-indolinone substituted in the 4-position by the ##STR9## side chain and R is ##STR10## where n' is 4 and the carbon atoms adjacent to the N atom are identically dialkylated by two lower alkyls of 1 to 4 carbon atoms or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
57 words
A compound of the formula ##STR8## wherein Het is 2-indolinone substituted in the 4-position by the ##STR9## side chain and R is ##STR10## where n' is 4 and the carbon atoms adjacent to the N atom are identically dialkylated by two lower alkyls of 1 to 4 carbon atoms or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
33 words
A compound of claim 1, in which R is ##STR11## where n' is 4 and the carbon atoms adjacent to the N atom are di-substituted with alkyl of 1 or 2 carbon atoms.
Claim 4
Dependent Claim
9 words
A compound of claim 1, wherein R is 2,2,6,6-Tetramethylpiperidino.
Claim 5
Dependent Claim
30 words
A pharmaceutical composition useful in the treatment of heart rhythm disorders comprising a therapeutically effective amount of a compound of claim 1 in association with a pharmaceutical carrier or diluent.
Claim 6
Dependent Claim
23 words
A pharmaceutical composition according to claim 4, useful in the treatment of heart rhythm disorder comprising 1 to 200 milligrams per unit dosage.
Claim 7
Dependent Claim
11 words
A pharmaceutical composition according to claim 4, wherein R is 2,2,6,6-tetramethylpiperidino.
Claim 8
Dependent Claim
30 words
A method of treating heart rhythm disorders in animals which comprises administering to an animal in need of such treatment a therapeutically effective amount of a compound of claim 1.
Claim 9
Dependent Claim
18 words
A method according to claim 7 in which 5 to 400 milligrams of the compound are administered daily.
Claim 10
Dependent Claim
20 words
A method according to claim 7 in which 1 to 200 milligrams of the compound are administered per unit dose.
Claim 11
Dependent Claim
10 words
A method according to claim 7 wherein R is 2,2,6,6-tetramethylpiperidino.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |