US4388314A
Expired / Lapsed
US
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Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-acylamido-3-cephem-4-carboxylic acid
Assignee: Pfizer Italia SRL
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Filing: 1981-08-21
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Granted: 1983-06-14
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Expires: 2001-08-21
Abstract
Abstract Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-ayclamide-3-cephem-4-carboxylic acid are disclosed, and process for preparing same. These compounds are suitable for treating infections caused by Gram-positive and Gram-negative microorganisms.
Inventors
- 👤 Giuliano Nannini
- 👤 Ettore Perrone
- 👤 Dino Severino
- 👤 Giuseppe Meinardi
- 👤 Gisella Monti
- 👤 Alberta Bianchi
- 👤 Angelo Forgione
- 👤 Carlo Confalonieri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:50
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/26; C07D501/28; C07C; C07C323/00; C07C323/50; C07C323/51; C07C323/60; A; A61; A61P; A61P31/00; A61P31/04; C07D501/36
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
54 words
A compound of the formula ##STR68## wherein E is ##STR69## Q is --C 2 H 5 ,--CH 2 --CH═CH 2 ,--CH═CH--CH 3 , or ##STR70## T is amino or --CH 2 COOH, and Z is cyano, or, when E is ##STR71## Z is cyano or carbamoyl, and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 2
Dependent Claim
54 words
A compound of the formula ##STR68## wherein E is ##STR69## Q is --C 2 H 5 ,--CH 2 --CH═CH 2 ,--CH═CH--CH 3 , or ##STR70## T is amino or --CH 2 COOH, and Z is cyano, or, when E is ##STR71## Z is cyano or carbamoyl, and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 3
Dependent Claim
40 words
A compound of claim 1, said compound of formula ##STR72## wherein Z is cyano or carbamoyl; Q is --C 2 H 5 , --CH 2 --CH═CH 2 , --CH═CH--CH 3 or ##STR73## and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 4
Dependent Claim
35 words
A compound as claimed in claim 2 wherein said compound is selected from the group consisting of: 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(1-ethyl-1,2,3,4-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid; 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(1-(2)-propenyl-1,2,3,4-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid; 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(1-(1)-propenyl-1,2,3,4-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid; 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(1-β-dimethylaminoethyl-1,2,3,4-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid; 7-[β-carboxamido-ethylene(cis)-thio-acetamido]-3-[(1-ethyl-1,2,3,4-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid, and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 5
Dependent Claim
26 words
A compound of claim 1, said compound of formula ##STR74## wherein T is amino or --CH 2 COOH, and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 6
Dependent Claim
29 words
A compound as claimed in claim 4 wherein said compound is selected from the group consisting of: 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(5-amino-1,3,4-thiadiazol-2-yl)-thiomethyl]-3-cephem-4-carboxylic acid; 7-[β-cyano-ethylene(cis)-thio-acetamido]-3-[(5-carboxymethyl-1,3,4-thiadiazol-2-yl)-thiomethyl]-3-cephem-4-carboxylic acid, and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 7
Dependent Claim
18 words
A compound of claim 1, said compound of formula ##STR75## and the pharmaceutically or veterinarily acceptable salts thereof.
Claim 8
Dependent Claim
51 words
A pharmaceutical or veterinary composition suitable for the treatment of infections caused by Gram-positive and Gram-negative microorganisms, said composition consisting essentially of a therapeutically effective amount of a compound according to any one of claims 1, 2, 3, 4, 5 or 6, and a pharmaceutically or veterinarily acceptable carrier or diluent.
Claim 9
Dependent Claim
42 words
Method for the treatment of an infection caused by Gram-positive or Gram-negative microorganisms in a patient, said method comprising administering to said patient a therapeutically effective amount of a compound of any one of claims 1, 2, 3, 4, 5 or 6.
Claim 10
Dependent Claim
12 words
Method of claim 8 wherein said compound is administered orally or parenterally.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-13 | 1986-12-13 | 1987-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-13 | 1990-12-13 | 1991-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-13 | 1994-12-13 | 1995-06-14 | $7700.00 | Window Closed / Lapsed |